Results 71 to 80 of about 1,464,688 (300)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Remote Sensing, 2018 Digital terrain models (DTMs) are a fundamental source of information in Earth sciences. DTM-based studies, however, can contain remarkable biases if limitations and inaccuracies in these models are disregarded.
Lukas Graf +7 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
Nature Communications, 2019 It is unclear how circuit specificity and function are maintained during organismal growth. In this study, authors show that connectivity between primary nociceptors and their downstream neurons scales with animal size and that Ste20-like kinase Tao acts
Federico Marcello Tenedini +13 more
doaj +1 more source
Spectral Bounds for the Connectivity of Regular Graphs with Given Order [PDF]
, 2018 The second-largest eigenvalue and second-smallest Laplacian eigenvalue of a graph are measures of its connectivity. These eigenvalues can be used to analyze the robustness, resilience, and synchronizability of networks, and are related to connectivity ...
Abiad, Aida +4 more
core +4 more sources
Regular connections among generalized connections [PDF]
Journal of Geometry and Physics, 2003 13 pages, 1 figure ...
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A Spatially Consistent MIMO Channel Model With Adjustable K Factor
IEEE Access, 2019 In the area of research on massive multiple-input multiple-output (MIMO), two assumptions on the wireless channel dominate channel modeling. Either, a rich scattering environment is assumed and the channel is modeled as i.i.d. Rayleigh fading, or, a line
Stefan Pratschner +6 more
doaj +1 more source
Exactly solvable model with two conductor-insulator transitions driven by impurities
, 2001 We present an exact analysis of two conductor-insulator transitions in the random graph model. The average connectivity is related to the concentration of impurities. The adjacency matrix of a large random graph is used as a hopping Hamiltonian.
A. Brooks Harris +6 more
core +3 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source