Results 61 to 70 of about 16,090 (228)

Connectomics and epilepsy [PDF]

Current Opinion in Neurology, 2013
Tremendous advances have occurred in recent years in elucidating basic mechanisms of epilepsy at the level of ion channels and neurotransmitters. Epilepsy, however, is ultimately a disease of functionally and/or structurally aberrant connections between neurons and groups of neurons at the systems level.
Jerome Engel, null Jr., Paul M. Thompson, John M. Stern, Richard J. Staba, Anatol Bragin, Istvan Mody   +6 more
openaire   +2 more sources

Monitoring voltage fluctuations of intracellular membranes

Scientific Reports, 2018
In eukaryotic cells, the endoplasmic reticulum (ER) is the largest continuous membrane-enclosed network which surrounds a single lumen. Using a new genetically encoded voltage indicator (GEVI), we applied the patch clamp technique to cultured HEK293 ...
Masoud Sepehri Rad, Lawrence B. Cohen, Oliver Braubach, Bradley J. Baker   +3 more
doaj   +1 more source

New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned

Frontiers in Ophthalmology, 2023
The retinal neural circuit is intricately wired for efficient processing of visual signals. This is well-supported by the specialized connections between retinal neurons at both the functional and ultrastructural levels.
Abhilash Sawant, Abhilash Sawant, Abhilash Sawant, Abhilash Sawant, Aindrila Saha, Aindrila Saha, Aindrila Saha, Jacob Khoussine, Jacob Khoussine, Jacob Khoussine, Jacob Khoussine, Raunak Sinha, Raunak Sinha, Raunak Sinha, Mrinalini Hoon, Mrinalini Hoon, Mrinalini Hoon   +16 more
doaj   +1 more source

A Message Passing Algorithm for the Minimum Cost Multicut Problem [PDF]

, 2017
We propose a dual decomposition and linear program relaxation of the NP -hard minimum cost multicut problem. Unlike other polyhedral relaxations of the multicut polytope, it is amenable to efficient optimization by message passing.
Andres, Bjoern, Swoboda, Paul
core   +4 more sources

Sequencing the Connectome

PLoS Biology, 2012
Connectivity determines the function of neural circuits. Historically, circuit mapping has usually been viewed as a problem of microscopy, but no current method can achieve high-throughput mapping of entire circuits with single neuron precision. Here we describe a novel approach to determining connectivity.
Zador, A. M., Dubnau, J., Oyibo, H. K., Zhan, H., Cao, G., Peikon, I. D.   +5 more
openaire   +5 more sources

Convergence Circuit Mapping: Genetic Approaches From Structure to Function

Frontiers in Systems Neuroscience, 2021
Understanding the complex neural circuits that underpin brain function and behavior has been a long-standing goal of neuroscience. Yet this is no small feat considering the interconnectedness of neurons and other cell types, both within and across brain ...
Jang Soo Yook, Jihyun Kim, Jihyun Kim, Jinhyun Kim, Jinhyun Kim   +4 more
doaj   +1 more source

Computing Scalable Multivariate Glocal Invariants of Large (Brain-) Graphs

, 2013
Graphs are quickly emerging as a leading abstraction for the representation of data. One important application domain originates from an emerging discipline called "connectomics". Connectomics studies the brain as a graph; vertices correspond to neurons (
Burns, Randal, Jung, Rex, Mhembere, Disa, Priebe, Carey E., Roncal, William Gray, Ryman, Sephira, Sussman, Daniel, Vogelstein, Joshua T., Vogelstein, R. Jacob   +8 more
core   +1 more source

Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0 [PDF]

Cognitive Neurodynamics, 2016
Connections of the living human brain, on a macroscopic scale, can be mapped by a diffusion MR imaging based workflow. Since the same anatomic regions can be corresponded between distinct brains, one can compare the presence or the absence of the edges, connecting the very same two anatomic regions, among multiple cortices.
Balázs Szalkai, Csaba Kerepesi, Bálint Varga, Vince Grolmusz   +3 more
openaire   +5 more sources

Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans

Advanced Science, EarlyView.
This study employs viral‐based single‐neuron tracing and dMRI‐based whole‐brain tractography to investigate arcuate fasciculus (AF) trajectories in macaque monkeys, and compares with the human AF connectome using spectral embedding. Results demonstrate conserved AF topography spanning temporoparietal‐auditory‐frontal pathways across primates, with ...
Jiahao Huang, Ruifeng Li, Wenwen Yu, Anan Li, Xiangning Li, Mingchao Yan, Lei Xie, Qingrun Zeng, Xueyan Jia, Shuxin Wang, Ronghui Ju, Feng Chen, Qingming Luo, Hui Gong, Andrew Zalesky, Xiaoquan Yang, Yuanjing Feng, Zheng Wang   +17 more
wiley   +1 more source

High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

eLife, 2023
Globular bushy cells (GBCs) of the cochlear nucleus play central roles in the temporal processing of sound. Despite investigation over many decades, fundamental questions remain about their dendrite structure, afferent innervation, and integration of ...
George A Spirou, Matthew Kersting, Sean Carr, Bayan Razzaq, Carolyna Yamamoto Alves Pinto, Mariah Dawson, Mark H Ellisman, Paul B Manis   +7 more
doaj   +1 more source