Results 71 to 80 of about 8,362 (210)

Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Deep brain stimulation of the fornix (fx‐DBS) is being investigated for treatment of Alzheimer's disease (AD). The therapy aims at alleviating memory and cognitive circuit dysfunction. In preclinical models of AD, electrical stimulation of the memory circuit has demonstrated a possible disease‐modifying potential. Here we examined
Jürgen Germann   +37 more
wiley   +1 more source

Physics, Emergence, and the Connectome [PDF]

open access: yesNeuron, 2014
Experience with complex systems more primitive than the brain teaches important lessons about big data in biology. Chief among them is that physical laws, relationships among measured things that are always true, emerge out of chaos, not the other way around.
openaire   +3 more sources

A 128‐channel receive array with enhanced signal‐to‐noise ratio performance for 10.5T brain imaging

open access: yesMagnetic Resonance in Medicine, Volume 93, Issue 6, Page 2680-2698, June 2025.
Abstract Purpose To develop and characterize a 128‐channel head array for brain imaging at 10.5 T, evaluate signal‐to‐noise ratio (SNR) relative to ultimate intrinsic SNR (uiSNR) and lower field strengths, and demonstrate human brain anatomical and functional imaging with this unique magnetic field and high‐channel‐count array.
Russell L. Lagore   +17 more
wiley   +1 more source

Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization.

open access: yesJournal of Neurophysiology, 2010
Resting state functional connectivity MRI (fcMRI) is widely used to investigate brain networks that exhibit correlated fluctuations. While fcMRI does not provide direct measurement of anatomic connectivity, accumulating evidence suggests it is ...
Koene R. A. van Dijk   +5 more
semanticscholar   +1 more source

Applications of MRI Connectomics

open access: yes, 2021
Structural and functional brain connectomics are considered a basis for an individual's behavior and cognition. Therefore, deviations from typical connectivity patterns may indicate disease processes, and can potentially serve as disease biomarkers. To date, the direct clinical application of brain connectivity measures for diagnostics or treatment is ...
Jessica S. Damoiseaux   +3 more
openaire   +4 more sources

The Connectome Mapper: An Open-Source Processing Pipeline to Map Connectomes with MRI [PDF]

open access: yesPLoS ONE, 2012
Researchers working in the field of global connectivity analysis using diffusion magnetic resonance imaging (MRI) can count on a wide selection of software packages for processing their data, with methods ranging from the reconstruction of the local intra-voxel axonal structure to the estimation of the trajectories of the underlying fibre tracts ...
Xavier Gigandet   +11 more
openaire   +9 more sources

Network Topography Alterations in Alzheimer's Disease: Insights From Motif Changes via Multisite Datasets (N = 3262)

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
This study identifies 20 undirected triangle motifs in the brain network using edge strength and length from the regional radiomics similarity network (R2SN) and introduces the Principal Motif Value (PMV) via principal component analysis (PCA). PMV significantly correlates with clinical and neurological features and is linked to gene expression in ...
Juntao Zhao   +13 more
wiley   +1 more source

Multifactorial interplay on language recovery following left‐hemispheric stroke: A retrospective study

open access: yesJournal of Neuropsychology, Volume 19, Issue 2, Page 256-273, June 2025.
Abstract Understanding the relative contribution of various factors influencing initial severity of aphasia and recovery after a stroke is essential for optimising neurorehabilitation programmes. We investigated how various significant sociodemographic, cognitive, clinical, stroke‐related and rehabilitation‐related factors modulate aphasia severity and
Célise Haldin   +6 more
wiley   +1 more source

Functional connectomics in depression: insights into therapies

open access: yesTrends in Cognitive Sciences, 2023
Y. Chai   +5 more
semanticscholar   +1 more source

Brain connectomics: time for a molecular imaging perspective?

open access: yesTrends in Cognitive Sciences, 2023
Arianna Sala   +10 more
semanticscholar   +1 more source

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