Results 101 to 110 of about 38,372 (307)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Cultural relevance of the emotive code in A.P. Chekhov’s story «The Student»: discursive strategies
Вестник Самарского университета: История, педагогика, филологияIntroduction. The relevance of studying the emotive code in the literary textual-discursive space is determined by the need to clarify the functional-semantic and communicative-pragmatic specifics of the category of emotiveness, which determines the key ...
A. I. Trubkina
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Menyingkap Makna dan Tanda dalam Iklan Rokok A-Mild Versi “Hasrat”: Kajian Semiotika
Ranah: Jurnal Kajian Bahasa, 2017 This semiotic study seeks to investigate how meanings and ideology in the A-Mild advertisement are represented through denotation, connotation and myth.
Fathin Shofa, Meina Astri Utami
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Figurative Meaning in Cultural Lexis: A Case Study
Odisea, 2017 La relación entre lengua y cultura es uno de los postulados de la lingüística moderna desde la teoría de Sapir-Whorf. Esta relación se manifi esta especialmente en el léxico.
Isabel Negro Alousque
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Connotation du nom propre, ou si Nicolas Chauvin était « chauviniste »
, 2011 Shokhenmayer Evgeny. Connotation du nom propre, ou si Nicolas Chauvin était « chauviniste ». In: Nouvelle revue d'onomastique, n°53, 2011. pp.
Shokhenmayer, Evgeny
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The semiotics of smartphone advertising: myth and ideology in YouTube commercials
Cogent Arts & HumanitiesThis study explores the semiotic construction of meaning in contemporary smartphone advertisements using Roland Barthes’ four-level model: denotation, connotation, myth and ideology.
Km Tri Sutrisna Agustia +4 more
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