Results 141 to 150 of about 38,372 (307)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

THE AUTONYMOUS CONNOTATION. SEMANTIC AND SYNTACTIC ASPECTS [PDF]

open access: yes, 2010
This paper aims at presenting one of the main characteristics of the natural language, that is its possibility to refer to everything, language included. Given the latter possibility, one can speak about reflexivity, which is one of the universals of the
Dr. Melania ROIBU
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Analysis of Connotation Words in The Jakarta Post Online Headline News

open access: yes
This research aims to analyse connotation words in the Jakarta Post online headline news and to find the positive and negative connotation of those online headline news. Qualitative method and descriptive analysis are applied in this research.
Eva Nurul Candra
core  

Sensitivity to musical denotation and connotation in organic patients.

open access: yes, 1977
Musical segments convey at least two kinds of meaning: The "real-world" events referred to by lyrics and by occasions of performance constitute musical denotation: the formal expressive patterns suggested by such constituents as pitch, timbre, and ...
G. Denes   +4 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

DYSPHEMISTIC DENTS AND EUPHEMISTIC ALIGNMENTS OF THE POETIC TEXT OF TATJANA GROMAČA

open access: yesFluminensia: Journal for Philological Research, 2010
This article is based on the research of the figurative fied of the poetic text of Tatjana Gromača. The anterior readings of this text were basically oriented on the critical and literary theorical researches and contextualization in the domain of the ...
Tin Lemac
doaj  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

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