Results 131 to 140 of about 38,372 (307)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Connotation of humanistic service and its application in nursing care
Huli yanjiu, 2005 Humanistic service as a revolution of service modes in the new century draws more and more attention of hospital administrators. The objects of hospital served for are human beings.
王秀梅, 范秋霞
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The essence and connotation of cultural care
Huli yanjiu, 2005 cultural care as a main part of nursing care,it directs the development of modern nursing science.It is what patients need for their health as well.This article analyzed both the essence and connotation of cultural care,distinguished caring behavior and ...
王菊吾 +4 more
doaj
Emotive phraseological units with negative connotation in British English [PDF]
, 2018 This article is devoted to emotive phrasiological units with negative connotation in British English. Moreover the article explains the reasons why some particular negative emotions prevail or not prevail among ...
Tratsiak, Z., Vianhura, L.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Connotation and Dynamism of the Linguistic Sign
, 2008 Статья посвящена проблеме порождения коннотации в результате двойственной природы и полифункциональности языкового знака. Автор рассматривает трактовку данного вопроса в концепциях У. Эко, Р. Барта и Э. Косериу. В заключение автор приходит к выводу о том,
Герасименко, И. Е. +1 more
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Names, 1978 (1978). Are there Connotative Names? Names: Vol. 26, In Honour of Professor Claude Henry Neuffer, pp. 40-47.
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source