Results 41 to 50 of about 6,359 (290)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii

eLife, 2020
The coccidian subgroup of Apicomplexa possesses an apical complex harboring a conoid, made of unique tubulin polymer fibers. This enigmatic organelle extrudes in extracellular invasive parasites and is associated to the apical polar ring (APR).
Nicolò Tosetti, Nicolas Dos Santos Pacheco, Eloïse Bertiaux, Bohumil Maco, Lorène Bournonville, Virginie Hamel, Paul Guichard, Dominique Soldati-Favre   +7 more
doaj   +1 more source

A parametrix for quantum gravity?

, 2016
In the sixties, DeWitt discovered that the advanced and retarded Green functions of the wave operator on metric perturbations in the de Donder gauge make it possible to define classical Poisson brackets on the space of functionals that are invariant ...
Esposito, Giampiero
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Huygens' Principle for the Klein-Gordon equation in the de Sitter spacetime

, 2012
In this article we prove that the Klein-Gordon equation in the de Sitter spacetime obeys the Huygens' principle only if the physical mass $m$ of the scalar field and the dimension $n\geq 2$ of the spatial variable are tied by the equation $m^2=(n^2-1)/4 $
Abramowitz M., Bateman H., Berkhahn F., Birrell N. D., Friedlander F. G., Friedrich H., Günther P., Günther P., Hawking S. W., Hörmander L., Karen Yagdjian, Lichnerowicz A., Møller C., Parker L. E., Shatah J., Tolman R. C., Yagdjian K.   +16 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Quantitative Assessment of the Distal Clavicle with Its Clinical Implications in Anatomical Reconstruction of the Coracoclavicular Ligament

Düzce Tıp Fakültesi Dergisi
Aim: Anatomical reconstruction of the coracoclavicular ligament has recently become popular in the treatment of acromioclavicular joint injuries. To perform this procedure correctly, the anatomy of the conoid tubercle and trapezoid line, which are the ...
Helin Yücedağ Gündoğdu, Hilal Akdemir Aktaş   +1 more
doaj   +1 more source

Hygrothermal Analysis of Laminated Composite Skew Conoids [PDF]

Materials, 2019
The present paper is the first study on the hygrothermal analysis (i.e., effect of temperature and moisture loadings) of laminated composite skew conoids with reasonable depth and thickness. In order to solve the hygrothermal problem of laminated composite skew conoids, the cubic variation in displacement field, along with cross curvature effects of ...
Abhay Chaubey, Ajay Kumar, Stanisław Fic, Danuta Barnat-Hunek, Barbara Sadowska-Buraczewska   +4 more
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Morphometric Study of Clavicular Facet of Coracoclavicular Joint in Adult Indian Population [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Anthropologists have used Coracoclavicular Joint (CCJ), a non-metric anatomical variant in population, as a marker for population migration from prehistoric times to present.
Sushant Swaroop Das, Anita Mahajan, Neelam Vasudeva   +2 more
doaj   +1 more source