Results 41 to 50 of about 6,961 (212)
European Psychiatry, 2021 There is a considerable overlap of psychotic and mood symptoms in patients with severe mental disorders, and a large proportion of patients meeting diagnostic criteria experience significant mood symptoms. The diagnosis of schizophrenia – schizoaffective type /schizoaffective disorder has been a part of the ...
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Explaining the pros and cons of different sources of Faculty Evaluation from the viewpoints of Medical University Academics [PDF]
Strides in Development of Medical Education, 2012 Background & Objectives: Nowadays improvement of teaching quality is one of the basics for a credible higher education system and without doubt evaluation and monitoring of teaching quality are important for reaching this goal However different studies ...
Ali Asghar Arabi Mianroodi +2 more
doaj
Revista X, 2015 O Ensino de Jovens e Adultos (EJA), mesmo que de extrema relevância e importância no contexto sócio histórico brasileiro, ainda se apresenta como um grande desafio para os educadores nas questões de adaptação dos alunos em sala de aula, de currículo e de
Thais Rodrigues Cons
doaj +1 more source
Características de carcaça e da carne de vacas de descarte de diferentes genótipos charolês x nelore, terminadas em confinamento [PDF]
Ciência Rural, 2003 O objetivo deste trabalho foi estudar as características de carcaça e da carne de vacas de diferentes graus de sangue Charolês (C) X Nelore (N), terminadas em confinamento. Foram utilizadas 25 vacas de descarte, dos seguintes genótipos: C, 3/4 C + 1/4 N,
João Restle +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source