Results 41 to 50 of about 166,564 (291)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The interaction of mithramycin with DNA
, 1990 Mithramycin is an antitumour antibiotic which acts by binding to double stranded DNA. It is known to bind to GC rich DNA sequences requiring the presence of a divalent metal ion.
Cons, Benjamin Major George
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Analysis of wooden pillar and wooden ceiling mosques of the Seljuk and principalities period
Journal of Design for Resilience in Architecture and PlanningMosques, as structures meticulously designed and constructed, represent the pinnacle of architectural and aesthetic solutions within Islamic civilizations.
Ercan Aksoy, Özlem Sağıroğlu Demirci
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Revista Brasileira de Zootecnia, 2001 O objetivo deste trabalho foi testar diferentes níveis de suplementação energética na forma de grão de sorgo moído, para a terminação em pastagem, de vacas de descarte de diferentes genótipos Charolês (C) x Nelore (N).
João Restle +5 more
doaj
Explaining the pros and cons of different sources of Faculty Evaluation from the viewpoints of Medical University Academics [PDF]
Strides in Development of Medical Education, 2012 Background & Objectives: Nowadays improvement of teaching quality is one of the basics for a credible higher education system and without doubt evaluation and monitoring of teaching quality are important for reaching this goal However different studies ...
Ali Asghar Arabi Mianroodi +2 more
doaj
Revista X, 2015 O Ensino de Jovens e Adultos (EJA), mesmo que de extrema relevância e importância no contexto sócio histórico brasileiro, ainda se apresenta como um grande desafio para os educadores nas questões de adaptação dos alunos em sala de aula, de currículo e de
Thais Rodrigues Cons
doaj +1 more source