Results 51 to 60 of about 166,564 (291)
Pros and Cons of the Proteomics
Biomedical Journal, 2013 The number of proteins produced by the 30,000-40,000 genes of the human genome is estimated to be three or four orders of magnitude higher. Proteomics is a rapidly developing science. In principle, two main areas in the field of proteomics have been developed, each of them having its pros and cons.
Ashish Gupta, Ashutosh Kumar
openaire +3 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Times of Chokepoints [PDF]
, 2018 Chokepoints are problems not only of space, but also of time. Jason Cons explores this temporality in Bangladesh’s Sundarbans, a mangrove forest that has become a laboratory for fashioning the future in a warming ...
Cons, Jason
core +1 more source
Notifications workflows using the CERN IT central messaging infrastructure [PDF]
EPJ Web of Conferences, 2019 In the CERN IT agile infrastructure (AI), Puppet, the CERN IT central messaging infrastructure (MI) and the Roger application are the key constituents handling the configuration of the machines of the computer centre.
Toteva Zhechka, Lukic Darko, Cons Lionel
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Características de carcaça e da carne de vacas de descarte de diferentes genótipos charolês x nelore, terminadas em confinamento [PDF]
Ciência Rural, 2003 O objetivo deste trabalho foi estudar as características de carcaça e da carne de vacas de diferentes graus de sangue Charolês (C) X Nelore (N), terminadas em confinamento. Foram utilizadas 25 vacas de descarte, dos seguintes genótipos: C, 3/4 C + 1/4 N,
João Restle +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source