Results 21 to 30 of about 27,924 (252)

Relationship of semen quality to inbreeding and gait of Colombian Creole horses

Ciência Rural, 2022
: High consanguinity among equines has negative effects on semen quality, thus resulting in low motility and high levels of abnormality in the spermatozoa.
Giovanni Restrepo Betancur, Katherine Bedoya Rodas, Alexandra Usuga Suarez   +2 more
doaj   +1 more source

The relationship between orofacial clefts and consanguineous marriages: A hospital register-based study in Dharwad, South India

Journal of Cleft Lip Palate and Craniofacial Anomalies, 2017
Context: Orofacial cleft (OFC) is one of the common craniofacial malformations. The etiology of these OFCs is multifactorial. One of the etiological factors is consanguinity (marriage between blood relatives).
B R Rajeev, K. V. V Prasad, Preetha J Shetty, Raman Preet   +3 more
doaj   +1 more source

Parental Consanguinity and Family History in Relation to Psoriasis and the Role of Sex: A Case-Control Study

Human Heredity
Introduction: Psoriasis is caused by an interplay between intrinsic and extrinsic factors. Parental consanguinity increases homozygosity in the genome of the offspring, which in turn increases disease risk.
Alanood N. AlKhas, Ali H. Ziyab
doaj   +1 more source

Consanguineous Marriages in Pakistan [PDF]

The Pakistan Development Review, 1994
In societies where marriage is nearly universal, and the fertility process is almost entirely through marital union, the factors associated with the occurrence of marriage, and through it the reproduction and rearing of children, need to be continuously assessed.
Mohammad Afzal, S. Mubashir Ali, H.B. Siyal   +2 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Consanguineous marriages, and the relationship between consanguineous

, 2011
Consanguineous marriages are common in Turkey. The rates and types of consanguineous marriages, and their relationship to abortions and infant mortality were investigated in Acipayam, a rural area of Denizli, Turkey. 795 families were interviewed using a pre-designed questionnaire. The total prevalence of consanguineous marriages is 17.5%.
Keskin, N, Bozkurt, AI, Keskin, A
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A founder COL4A3 pathogenic variant resulting in Alport syndrome and thin basement membrane disease: a case report series

Frontiers in Medicine, 2023
Alport syndrome is a rare genetic condition characterized by kidney disease, hearing impairment, and ocular abnormalities. It exhibits various inheritance patterns involving pathogenic variants in COL4A3, COL4A4, and COL4A5 genes.
Tinatin Tkemaladze, Tinatin Tkemaladze, Kakha Bregvadze, Eka Kvaratskhelia, Elene Abzianidze, Tinatin Davitaia   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source