Results 31 to 40 of about 52,020 (257)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Frontiers in Medicine, 2023 Alport syndrome is a rare genetic condition characterized by kidney disease, hearing impairment, and ocular abnormalities. It exhibits various inheritance patterns involving pathogenic variants in COL4A3, COL4A4, and COL4A5 genes.
Tinatin Tkemaladze +5 more
doaj +1 more source
Prevalence and Pattern of Consanguineous Marriages Among Different Communities in Mangalore [PDF]
, 2013 Introduction: Consanguineous marriages are a common practice in the Middle East, Asian and African populations. Many studies have stated an association between first cousin marriages and the incidence of autosomal recessive diseases and congenital ...
Avadhani, R, Bhagya, B, Sucharitha, S
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Consanguinity in the Maltese Islands [PDF]
, 2015 Consanguineous marriages may increase the risk of some medical conditions and may be useful to examine social and other aspects. There were few such marriages in the Maltese islands until late in the 19th C when they increased until they began to decline
Wyatt, H.V.
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Consanguinity and its Effects : The Love That Dare Not Speak Its Surname! [PDF]
Perspectives In Medical Research, 2017 Introduction: Consanguineous marriage means marrying biologically related or blood relatives. Consanguinity is a deeply rooted trend in the South Indian States.
N Sreeja1 , Rupshikha Dutta2
doaj
The changing pattern and determinants of declining consanguinity in Jordan during 1990–2012
Annals of Human Biology, 2018 Background: Consanguinity is a deep rooted cultural trait in Jordan. Aim: To examine the patterns and determinants of declining rates of consanguineous marriage in Jordan during 1990–2012 in the context of the changing pattern of socio-economic and ...
M. Mazharul Islam
doaj +1 more source
Consanguineous marriage, prepregnancy maternal characteristics and stillbirth risk: A population-based case-control study [PDF]
, 2015 Introduction. Consanguineous marriage is associated with increased risks for congenital anomalies, low birthweight, and other adverse perinatal outcomes.
Aarabi, M. +7 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source