Results 111 to 120 of about 1,595,902 (305)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

The centre and periphery of conscious thought [PDF]

, 2018
This paper is about whether shifts in attention can alter what it is like to think. I begin by taking up the hypothesis that attention structures consciousness into a centre and a periphery, following Watzl's (2014; 2017) understanding of the distinction
Fortney, Mark
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Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

The Rhode Island Charter and Roger Williams’s Legacy [PDF]

, 2013
Historians, scholars and a legal expert illuminate Roger Williams’s influence on the American principles of freedom of conscious and limited government that continue to both resonate and cause tension ...
Rodrigues, Jill
core   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

“The Stone Flower”: the power of beauty between truth and fantasy

Studia Humanitatis, 2016
The life of Russian writer Pavel Petrovich Bazhov (1879-1950) was marked by important historical events: the decline of the Russian Empire and the Great Revolution, which brought to the rise of the Soviet Union.
Fusco Amedea
doaj  

Comportamento alimentar na gestação e sua relação com o peso da criança ao nascer

Revista Contexto & Saúde
Avaliar a relação entre comportamentos alimentares durante o período gestacional com o peso ao nascer do bebê. Estudo transversal realizado com gestantes atendidas na rede pública e privada de Lavras-Minas Gerais.
Laudicéia Ferreira Fróis, Nathália Luíza Ferreira, Lydiane Bragunci Bedeschi, Nathália Stahlschmidt Petry, Lilian Gonçalves Teixeira   +4 more
doaj   +1 more source

IT Innovativeness and Environmental Consciousness on Organizational Performance [PDF]

The purpose of our study is to investigate the impacts of Information Technology (IT) innovation and environmental consciousness on firm performance. We tested the robustness of innovation theory using the most recent Information Week (IW) 500 annual ...
Myung Ko
core