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Biology of Consciousness [PDF]

Frontiers in Psychology, 2011
The Dynamic Core and Global Workspace hypotheses were independently put forward to provide mechanistic and biologically plausible accounts of how brains generate conscious mental content. The Dynamic Core proposes that reentrant neural activity in the thalamocortical system gives rise to conscious experience.
Gerald M. Edelman, Bernard J. Baars, Joseph A. Gally   +2 more
openaire   +3 more sources

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Estimating the Minimal Number of Repeated Examinations for Random Responsiveness With the Coma Recovery Scale—Revised as an Example

Frontiers in Integrative Neuroscience, 2021
Objective: The aim of this study was to develop a general method to estimate the minimal number of repeated examinations needed to detect patients with random responsiveness, given a limited rate of missed diagnosis.Methods: Basic statistical theory was ...
Hao Yang, Chengyin Ye, Xiaochen Liu, Lingxiu Sun, Anqi Wang, Jing Wang, Nantu Hu, Xiaohua Hu, Olivia Gosseries, Steven Laureys, Haibo Di, Jiqian Fang   +11 more
doaj   +1 more source

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

Needs and Quality of Life of Caregivers of Patients with Prolonged Disorders of Consciousness

Brain Sciences, 2023
Background. Many patients with severe brain damage may survive and remain in a prolonged disorder of consciousness (PDoC), impacting the quality of life (QoL) and needs of their family caregivers.
Olivia Gosseries, Caroline Schnakers, Audrey Vanhaudenhuyse, Charlotte Martial, Charlène Aubinet, Vanessa Charland-Verville, Aurore Thibaut, Jitka Annen, Didier Ledoux, Steven Laureys, Charlotte Grégoire   +10 more
doaj   +1 more source

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

Clinical Research: Auditory Stimulation in the Disorders of Consciousness

Frontiers in Human Neuroscience, 2019
Due to the complex situation of disorder of consciousness (DOC) patients, the assessment of conscious states of these patients has become a huge challenge for a long time (Laureys et al., 2010).
Jiajie Zhu, Yifan Yan, Wei Zhou, Yajun Lin, Zheying Shen, Xuanting Mou, Yan Ren, Xiaohua Hu, Haibo Di   +8 more
doaj   +1 more source

Neurophysiological Correlates of a Single Session of Prefrontal tDCS in Patients with Prolonged Disorders of Consciousness: A Pilot Double-Blind Randomized Controlled Study

Brain Sciences, 2020
Background. Transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) was reported to promote the recovery of signs of consciousness in some patients in a minimally conscious state (MCS), but its ...
Manon Carrière, Sepehr Mortaheb, Federico Raimondo, Jitka Annen, Alice Barra, Maria C. Binda Fossati, Camille Chatelle, Bertrand Hermann, Géraldine Martens, Carol Di Perri, Steven Laureys, Aurore Thibaut   +11 more
doaj   +1 more source

Brain magnetic resonance imaging predictors in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1974-1984, December 2022., 2022
Abstract Objective Brain magnetic resonance imaging (MRI) findings in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with NMDAR encephalitis, examine their associations with ...
Ying‐Ying Zhao, Bing Han, Cui‐Hong Qin, Xue‐Xiu Shi, Wen‐Jing Yun, Meng Wang, Bo Yuan, Tong‐Wen Sun, Hai‐Xu Wang   +8 more
wiley   +1 more source

Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness

Frontiers in Systems Neuroscience, 2020
Due to life-saving medical advances, the diagnosis and treatment of disorders of consciousness (DOC) has become a more commonly occurring clinical issue.
Armand Mensen, Olivier Bodart, Olivier Bodart, Aurore Thibaut, Aurore Thibaut, Aurore Thibaut, Sarah Wannez, Jitka Annen, Steven Laureys, Steven Laureys, Olivia Gosseries, Olivia Gosseries   +11 more
doaj   +1 more source