Results 41 to 50 of about 267,727 (265)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Systematic ReviewsObjective To accurately predict neurological outcomes among survivors after cardiac arrest (CA), we aim to analyze the experimental data of epileptiform electroencephalography (EEG) in CA survivors to explore the value of predictors of epileptiform EEG ...
Jiayi Lin +10 more
doaj +1 more source
Exploring end-of-life decision-making in China for disorders of consciousness
Annals of MedicineObjectives We aim to investigate the ethical attitudes of the Chinese population toward withdrawal of life-sustaining treatment (WLST) in disorders of consciousness (DoC) patients.Methods A self-administered questionnaire concerning WLST was distributed ...
Meiqi Li +8 more
doaj +1 more source
Consciousness of Time and the Time of Consciousness
, 2009 This entry reviews different explanations of what consciousness must be like if it is possible for us to experience time and temporal objects such as melodies. Consciousness is characterized by a temporal structure and seems to involve a successive flow - the often-used metaphor of a stream of consciousness.
unknown ( host institution ) +1 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Chinese translation and validation of the Near-Death Experience Content scale
Frontiers in PsychiatryIntroductionIn recent years, a growing number of near-death experience (NDE) testimonies have been collected worldwide due to an increasing interest in research on this phenomenon.
Yan Li +16 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Near‐Death Experience During Emergency Ketamine Use: A Case Report
Brain and BehaviorPurpose Survivors from acute life‐threatening conditions occasionally report various alterations in subjective experiences, ranging from visual perceptual changes to multi‐faceted phenomena that can be categorized as near‐death experiences (NDEs).
Pauline Fritz +7 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Losing the Self in Near-Death Experiences: The Experience of Ego-Dissolution
Brain Sciences, 2021 Many people who have had a near-death experience (NDE) describe, as part of it, a disturbed sense of having a “distinct self”. However, no empirical studies have been conducted to explore the frequency or intensity of these effects.
Charlotte Martial +6 more
doaj +1 more source