Results 31 to 40 of about 3,010 (299)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Etyka w drzewie życia w ujęciu prof. Marii Ossowskiej

open access: yesFides et Ratio, 2018
Prof. Maria Ossowska (1896-1974) consecrated her professional life to study and teach the science of morality described by Descartes (1596-1650) in the metaphor of a philosophical tree: physics is the trunk, metaphysics the roots, ethics one of the ...
Bogusława Filipowicz
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Osesp anD Cu ltura Artística: two models

open access: yesRevista da Tulha, 2015
The restructuring of the São Paulo Symphony Orchestra (Osesp) caused an important growth and consolidation cycle in the musical life of the city, with important repercussions at the national level.
Ricardo Indig Teperman
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

John, Bishop of the Eastern Old Believer Church in Poland

open access: yesИзвестия Уральского федерального университета. Серия 2: Гуманитарные науки, 2020
The aim of this article is to present the personality of Ignacy Jan Wysoczański, an outstanding adventurist who frequently changed his religion, was twice ordained as a priest, and behaved immorally (he spent three and a half years in prison and had ...
Zoja Jaroszewicz-Pieresławcew
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Sources of renewal of the consecrated life

open access: yes, 2019
Kryzys życia konsekrowanego łączy się ściśle z kryzysem współczesnego człowieka oraz kryzysem Kościoła. Osłabienie wiary i wierności wybranemu powołaniu skutkuje brakiem świadectwa i w jakiejś mierze wpływa również na spadek liczby powołań. Zarówno słowo
Poleszak, Leszek
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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