Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Expert Consensus on the Clinical Utilization of Ketamine and Its Isomers in Intensive Care Units
Intensive Care ResearchAnalgesia and sedation are important treatment strategies in the intensive care unit (ICU). Due to the opioid crisis, opioid-sparing medications become the focus of clinical studies.
Zhiyong Peng +3 more
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FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
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HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
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An introduction to the Old Testament: the canon and Christian imagination [PDF]
, 2006 Title: An introduction to the Old Testament: the canon and Christian imagination. Author: Brueggemann, Walter Introduction to the Old Testament xiv, 417 p.
Uitti, Roger W.
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First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) [PDF]
, 2016 Christoph Rageth +15 more
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Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
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How to reach a compromise solution on technical and non-structural flood control measures
Soil and Water Research, 2014 Harmful impacts of floods are the result of an interaction between extreme hydrological events and environmental, social, and economic processes. Flood management should consider many diverse aspects and influences and an integrated approach to flood ...
Pavel KOVÁŘ +3 more
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Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
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Consensus Decision-Making and its Possibilities in Libraries
In the Library with the Lead Pipe, 2012 Introduction Since Occupy Wall Street finally started getting mainstream media coverage, the idea of consensus decision-making seems to have permeated our American psyche.
Emily Ford
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