Results 61 to 70 of about 3,095,141 (299)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A simulated annealing algorithm for finding consensus sequences

, 2002
Motivation: A consensus sequence for a family of related sequences is, as the name suggests, a sequence that captures the features common to most members of the family.
Kroese, Dirk P., Kroese, Dirk P, Cochran, Duncan A., Bryant, Darryn, Keith, Jonathan M., Adams, Peter, Keith, Jonathan M, Cochran, Duncan A. E., Mitchelson, Keith R, Mitchelson, Keith R., Lala, Gita H.   +10 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Distributed Low-Carbon Economic Dispatch for Integrated Energy System Based on Homomorphic Encryption

Zhongguo dianli
To address the privacy leakage problem in the distributed scheduling process of the integrated energy system (IES), a fully consensus low-carbon economic dispatching method based on homomorphic encryption is proposed with consideration of the power ...
Jingcheng HU, Yunhao FAN, Tong ZHU, Zhenping CHEN   +3 more
doaj   +1 more source

Delegated Proof of Stake With Downgrade: A Secure and Efficient Blockchain Consensus Algorithm With Downgrade Mechanism

IEEE Access, 2019
Blockchain technology has a wide range of applications in the fields of finance, credit reporting and intellectual property, etc. As the core of blockchain, consensus algorithm affects the security and performance of blockchain system directly.
Fan Yang, Wei Zhou, QingQing Wu, Rui Long, Neal N. Xiong, Meiqi Zhou   +5 more
doaj   +1 more source

A Consensus Approach to Distributed Convex Optimization in Multi-Agent Systems [PDF]

, 2013
In this thesis we address the problem of distributed unconstrained convex optimization under separability assumptions, i.e., the framework where a network of agents, each endowed with local private convex cost and subject to communication constraints ...
Filippo Zanella, Zanella, Filippo
core  

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Optimization of PBFT Algorithm Based on QoS-Aware Trust Service Evaluation

Sensors, 2022
In service-transaction scenarios, blockchain technology is widely used as an effective tool for establishing trust between service providers and consumers. The consensus algorithm is the core technology of blockchain.
Wei Liu, Xuhao Zhang, Wenlong Feng, Mengxing Huang, Yun Xu   +4 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source