Results 71 to 80 of about 1,646,172 (334)

Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference

World Journal of Emergency Surgery, 2017
This paper reports on the consensus conference on the management of intra-abdominal infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual World Society of Emergency Surgery (WSES) meeting. This document covers all
Massimo Sartelli, Fausto Catena, Fikri M. Abu-Zidan, Luca Ansaloni, Walter L. Biffl, Marja A. Boermeester, Marco Ceresoli, Osvaldo Chiara, Federico Coccolini, Jan J. De Waele, Salomone Di Saverio, Christian Eckmann, Gustavo P. Fraga, Maddalena Giannella, Massimo Girardis, Ewen A. Griffiths, Jeffry Kashuk, Andrew W. Kirkpatrick, Vladimir Khokha, Yoram Kluger, Francesco M. Labricciosa, Ari Leppaniemi, Ronald V. Maier, Addison K. May, Mark Malangoni, Ignacio Martin-Loeches, John Mazuski, Philippe Montravers, Andrew Peitzman, Bruno M. Pereira, Tarcisio Reis, Boris Sakakushev, Gabriele Sganga, Kjetil Soreide, Michael Sugrue, Jan Ulrych, Jean-Louis Vincent, Pierluigi Viale, Ernest E. Moore   +38 more
doaj   +1 more source

Natural Design of a Stabilized Cross‐β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats

Advanced Materials, EarlyView.
We report a 3.2 Å cryoEM structure of functional amyloid protein FapC from Pseudomonas sp. UK4, an essential component of bacterial biofilm, which reveals a Greek key‐shaped protofilament, supports bioinformatically determined motifs, nuances AlphaFold predictions, emphasizes heterogeneous cross‐β stacking in amyloid cross‐seeding and shows strain ...
Yanting Jiang, Samuel Peña‐Díaz, Zhefei Zhang, Anders Ogechi Hostrup Daugberg, Marcos López Hernández, Janni Nielsen, Qiaojie Huang, Shenghan Qin, Morten K. D. Dueholm, Mingdong Dong, Jan Skov Pedersen, Qin Cao, Daniel E. Otzen, Huabing Wang   +13 more
wiley   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

Advanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang   +11 more
wiley   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

Advanced Science, EarlyView.
This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee, Rut Tejero, Nathaniel Silvia, Anirudh Sattiraju, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou, Guohao Dai   +10 more
wiley   +1 more source

The process and criteria for diagnosing specific learning disorders: indications from the Consensus Conference promoted by the Italian National Institute of Health

Annali dell'Istituto Superiore di Sanità, 2014
A Consensus Conference on Specific Learning Disorders has been promoted by the Italian National Institute of Health (Istituto Superiore di Sanità, ISS). The Consensus Conference consisted in a systematic review of the international literature addressing ...
Maria Luisa Lorusso, Mirta Vernice, Marina Dieterich, Daniela Brizzolara, Enrica Mariani, Salvatore De Masi, Franca D'Angelo, Eleonora Lacorte, Alfonso Mele   +8 more
doaj   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Time for a Consensus Conference on pain in neurorehabilitation.

European journal of physical and rehabilitation medicine, 2016
Pain represents a common problem in the setting of neurorehabilitation, in that it is a common outcome measure but may also have a negative effect on motor and cognitive outcomes. Guidelines, expert opinions or consensus statements on pain in neurorehabilitation are largely lacking. The Italian Consensus Conference on Pain in Neurorehabilitation (ICCPN)
Sandrini G, Tamburin S, Paolucci S, Boldrini P, Saraceni VM, Smania N, Italian Consensus Conference on Pain in Neurorehabilitation, Agostini M, Alfonsi E, Aloisi AM, Alvisi E, Aprile I, Armando M, Avenali M, Azicnuda E, Barale F, Bartolo M, Bergamaschi R, Berlangieri M, Berlincioni V, Berliocchi L, Berra E, Berto G, Bonadiman S, Bonazza S, Bressi F, Brugnera A, Brunelli S, Buzzi MG, Cacciatori C, Calvo A, Cantarella C, Caraceni AT, Carone R, Carraro E, Casale R, Castellazzi P, Castelnuovo G, Castino A, Cella M, Cerbo R, Chiò A, Ciotti C, Cisari C, Coraci D, Dalla Toffola E, Defazio G, De Icco R, Del Carro U, Dell’Isola A, De Tanti A, D’Ippolito M, Fazzi E, Federico A, Ferrari A, Ferrari S, Ferraro F, Formaglio F, Formisano R, Franzoni S, Gajofatto F, Gandolfi M, Gardella B, Geppetti P, Giammò A, Gimigliano R, Giusti EM, Greco E, Ieraci V, Invernizzi M, Jacopetti M, Jedrychowska I, Lacerenza M, La Cesa S, Lobba D, Magrinelli F, Mandrini S, Manera U, Manzoni GM, Marchettini P, Marchioni E, Mariotto S, Martinuzzi A, Masciullo M, Mezzarobba S, Miotti D, Modenese A, Molinari M, Monaco S, Morone G, Nappi R, Negrini S, Pace A, Padua L, Pagliano E, Palmerini V, Paolucci S, Pazzaglia C, Pecchioli C, Pietrabissa G, Picelli A, Polli A, Porro CA, Porru D, Romano M, Roncari L, Rosa R, Saccavini M, Sacerdote P, Sandrini G, Saviola D, Schenone A, Schweiger V, Scivoletto G, Smania N, Solaro C, SPALLONE, VINCENZA, Springhetti I, Tamburin S, Tassorelli C, Tinazzi M, Togni R, Torre M, Torta R, Traballesi M, Trabucco E, Tramontano M, Truini A, Tugnoli V, Turolla A, Valeriani M, Vallies G, Verzini E, Vottero M, Mario P.   +134 more
openaire   +12 more sources

The Italian Consensus Conference on Pain in Neurorehabilitationtion

Reviews in Health Care, 2015
Pain is frequent in several neurological conditions, such as stroke, Parkinson’s disease, multiple sclerosis, diabetic neuropathy, but it is often underestimated and therefore untreated or not successfully treated. Pain reduces quality of life, it may be the cause of adaptive disorders (such as anxiety and depression) and, in patients undergoing ...
Buzzi M. G., Tamburin S., Sandrini G.
openaire   +5 more sources