Results 81 to 90 of about 1,646,172 (334)

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

The Italian Consensus Conference on Pain in Neurorehabilitation: rationale and methodology

Journal of Pain Research, 2016
Stefano Tamburin,1 Stefano Paolucci,2 Francesca Magrinelli,1 Massimo Musicco,2,3 Giorgio Sandrini4,5 On behalf of the Italian Consensus Conference on Pain in Neurorehabilitation (ICCPN) 1Department of Neurological, Biomedical and Movement Sciences ...
Tamburin S, Paolucci S, Magrinelli F, Musicco M, Sandrini G   +4 more
doaj  

ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up

Annals of Oncology, 2018
The European Society for Medical Oncology (ESMO) consensus conference on testicular cancer was held on 3-5 November 2016 in Paris, France. The conference included a multidisciplinary panel of 36 leading experts in the diagnosis and treatment of ...
F. Honecker, J. Aparicio, D. Berney, J. Beyer, C. Bokemeyer, R. Cathomas, N. Clarke, G. Cohn-Cedermark, G. Daugaard, K. Dieckmann, K. Fizazi, S. Fosså, J. Germá-Lluch, P. Giannatempo, J. Gietema, S. Gillessen, H. Haugnes, Axel Heidenreich, K. Hemminki, R. Huddart, M. Jewett, F. Joly, J. Lauritsen, Anja Lorch, A. Necchi, N. Nicolai, C. Oing, J. Oldenburg, D. Ondruš, A. Papachristofilou, T. Powles, A. Sohaib, O. Ståhl, T. Tandstad, G. Toner, A. Horwich   +35 more
semanticscholar   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Breast Cancer Research and Treatment, 2018
PurposeThe second International Consensus Conference on B3 lesions was held in Zurich, Switzerland, in March 2018, organized by the International Breast Ultrasound School to re-evaluate the consensus recommendations.MethodsThis study (1) evaluated how ...
C. Rageth, E. O’Flynn, K. Pinker, R. Kubik-Huch, A. Mundinger, T. Decker, C. Tausch, F. Dammann, P. Baltzer, E. Fallenberg, M. Foschini, S. Dellas, M. Knauer, C. Malhaire, Martin J. Sonnenschein, Andreas Boos, E. Morris, Z. Varga   +17 more
semanticscholar   +1 more source

Discovery to Engineering of Mycotoxin Deoxynivalenol Degrading Enzymes Based on the Specialized Glyoxalase I

Advanced Science, EarlyView.
Deoxynivalenol (DON), a prevalent food mycotoxin, is an important risk factor in global food safety. A molecular phylogeny‐guided engineering approach is devised to repurpose specialized glyoxalase I (SPG) as a DON deactivator. Engineered SPG variants demonstrate superior stability and are highly capable of converting DON into less toxic products ...
Seung Hee Lee, Song Lim Ham, Kyoungmi Oh, Hyojin Park, Young‐Seo Kang, Tae‐Joo Yang, Taekyung Kim, Jonghwan Kim, Gyu Sung Lee, Min‐Jeong Lee, Jin‐Byung Park, Chung Sub Kim, Nam Yoon Kim   +12 more
wiley   +1 more source

Scientific people named in the classification of vasculitis

Revista Brasileira de Reumatologia
The first International Chapel Hill Consensus Conference was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis.
Gokhan Sargin, Taskin Senturk
doaj   +1 more source

Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis

Liver transplantation, 2019
Liver transplantation (LT) for alcohol associated hepatitis (AH) remains controversial. We convened a consensus conference to examine various aspects of LT for AH.
S. Asrani, J. Trotter, J. Lake, Aijaz Ahmed, A. Bonagura, A. Cameron, A. DiMartini, S. Gonzalez, G. Im, Paul L. Martin, P. Mathurin, Jessica L. Mellinger, J. Rice, V. Shah, N. Terrault, A. Wall, Scott Winder, G. Klintmalm   +17 more
semanticscholar   +1 more source

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
wiley   +1 more source