Results 111 to 120 of about 6,708,642 (339)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Notches on the dial: a call to action to develop plain language communication with the public about users and uses of health data

International Journal of Population Data Science, 2019
Population data science [1] researchers are not alone in recognizing the value of health and health-related data. In the era of big data, and with advent of machine learning and other artificial intelligence methods, organizations around the world are ...
P Alison Paprica, Kimberlyn McGrail, Michael J Schull, Dr.   +2 more
doaj   +1 more source

Written informed consent in patients with breast cancer [PDF]

, 1979
Hyman B. Muss, Dougľas R. White, Robert Michielutte, Frederick Richards, M. Robert Cooper, Sarah Williams, John J. Stuart, Charles L. Spurr   +7 more
openalex   +1 more source

Clinical adolescent decision-making: parental perspectives on confidentiality and consent in Belgium and The Netherlands

, 2022
Jana Vanwymelbeke, David De Coninck, Koen Matthijs, Karla Van Leeuwen, Steven Lierman, Ingrid Boone, Peter de Winter, Jaan Toelen   +7 more
openalex   +2 more sources

Rethinking the Principle of Fair Play [PDF]

, 2018
The principle of fair play is widely thought to require simply that costs and benefits be distributed fairly. This gloss on the principle, while not entirely inaccurate, has invited a host of popular objections based on misunderstandings about fair play.
Tosi, Justin
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

La reconnaissance d’autrui comme prérequis à toute forme de consentement et d’assentiment : Une réponse à Verpaelst et Touyz

BioéthiqueOnline, 2015
Medicine creates a tacit contract of appropriation of the medicalized body that consent forms simply formalize. The story of Frank Verpaelst highlights the primacy of the need for recognition that is inherent to the doctor/patient encounter, whether in ...
Couture, Vincent
doaj  

La citoyenneté des Anglaises, 1850-1914. À la conquête de l’opinion publique

Revue Française de Civilisation Britannique
Following the publication of Mary Wollstonecraft’s Vindication of the Rights of Woman (1792), the women’s suffrage campaign was forged around the slogan “on the same terms as men”.
Myriam Boussahba
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Constitutional Legitimacy [PDF]

, 2003
The problem of constitutional legitimacy is to establish why anyone should obey the command of a constitutionally-valid law. A lawmaking system is legitimate if there is a prima facie duty to obey the laws it makes. Neither consent of the governed nor
Barnett, Randy E.
core   +1 more source