Results 131 to 140 of about 578,367 (300)
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Gabriel Tremblay,1 Mike Dolph,1 Menaka Bhor,2 Qayyim Said,2 Anuja Roy,2 Brian Elliott,3 Andrew Briggs4 1Health Economics, Purple Squirrel Economics, New York, NY, USA; 2Health Economics and Outcomes Research, Novartis Pharmaceuticals, East
Said Q +6 more
core
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Imperatives and Logical Consequence [PDF]
The interrelated logical concepts of validity, entailment, and consequence are all standardly defined in terms of truth preservation. However, imperative sentences can stand in these relations, but they are not truth-apt (they do not express propositions)
Clark-Younger, Hannah
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A non-transitive relevant implication corresponding to classical logic consequence
In this paper we first develop a logic independent account of relevant implication. We propose a stipulative denition of what it means for a multiset of premises to relevantly L-imply a multiset of conclusions, where L is a Tarskian consequence relation:
Samonek, Aleksandra +2 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Happiness is more a cause than a consequence of career success
Is happiness a consequence or a cause of career success? Lisa C. Walsh, Julia K. Boehm, and Sonja Lyubomirsky find evidence to the latter. However, they warn that hiring visibly cheerful people or pressuring employees to act happy is not the soultion ...
Lyubomirsky, Sonja +2 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Consequence relations and admissible rules
This paper contains a detailed account of the notion of admissibility in the setting of consequence relations. It is proved that the two notions of admissibility used in the literature coincide, and it provides an extension to multi–conclusion ...
Iemhoff, R.
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