Results 121 to 130 of about 2,681,264 (318)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Cardiovascular consequences of obesity: how will the UK cope?
, 2013 Summary: it is estimated that by 2050, the majority of Britain’s population will be obese. In this article, Dr Henry Purcell discusses the cardiovascular consequences of obesity and what needs to be done to equip healthcare professionals with the tools ...
Henry Purcell
core +1 more source
Consequences and Coping Strategies Among Students and Workers Experiencing Stalking [PDF]
Iranian Rehabilitation JournalObjectives: This study aimed to compare the experience of stalking victimization among students and workers, considering the prevalence of the phenomenon, physical and emotional consequences, and coping strategies Methods: A total of 291 students (51.9%)
Daniela Acquadro Maran +7 more
doaj
Abstract This chapter examines how the meanings of voting influence turnout as well as other forms of participation, such as, working for a political party or protesting. The findings show a clear link between voting meanings and political participation. Viewing voting as meaningful is positively related to turnout. Additionally, holding
Brunetti, Anna Lia +2 more
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
, 2019 Introduction: Fetal environments play significant roles in determining adult well-being, particularly as they relate to non-communicable diseases and skill formation.
Mani, Subha +2 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source