Results 101 to 110 of about 2,681,264 (318)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Clocks & SleepSleep is an essential part of everyday life and disturbed sleep can produce numerous deleterious effects on the body. An especially prevalent and detrimental subset of sleep disturbances are sleep disturbances that occur in patients during the ...
Michael J. Nelson +4 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The causes and consequences of gangland violence in the Republic of Ireland [PDF]
, 2019 While the Republic of Ireland is a relatively peaceful country, with a homicide rate significantly lower than the global average, it has experienced a number of violent feuds between criminal gangs.
Windle, James
core
Consequences of bullying on the life and health of the person being bullied
Fides et RatioOne of the most serious pathologies in the work environment is bullying. Victims of mobbing experience emotional, psychological and sometimes even physical violence, which causes consequences on an individual, organizational, social level.
Iwona Szczęsna
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Terror threat perception and its consequences in contemporary Britain
, 2005 The terrorist attacks of 9/11, and subsequent terrorist acts around the world, have alerted social psychologists to the need to examine the antecedents and consequences of terrorist threat perception. In these two studies we examined the predictive power
Goodwin, R, Gaines, SO, Wilson, M
core
Модели, системы, сети в экономике, технике, природе и обществеBackground. The work is devoted to the problem of evaluating the effectiveness of extinguishing open fires of solid combustible substances and materials, as well as internal (closed) fires (if it is impossible to ensure the sealing of the protected ...
D.V. Stolyarov +3 more
doaj +1 more source
Frontiers in PsychologyAgainst the backdrop of global labor market volatility, Job Search Self-Efficacy (JSSE) is critical for job seekers’ persistence and success. Guided by Social Cognitive Theory (SCT) and Social Cognitive Career Theory (SCCT), this scoping review ...
Xiaojian Zheng +2 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source