Results 81 to 90 of about 2,681,264 (318)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Coalfields regeneration Dealing with the consequences of industrial decline
, 2000 Full report 'Coalfields regeneration: dealing with the consequences of industrial decline' by K. Bennett et al, published by The Policy PressAvailable from British Library Document Supply Centre-DSC:3927.734141(450) / BLDSC - British Library Document ...
Joseph Rowntree Foundation, York (United Kingdom)
core
Explaining the unintended consequences of public sector reform
, 2009 Purpose – The process of public sector reform in the United Kingdom continues to provoke debate. Even among advocates of the reform process there is a concern that improvements in public service provision have not been as marked as originally intended ...
Ghobadian, A. +8 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Globalisation of R&D and Technology Markets - Trends, Motives, Consequences
, 2022 S.37-78On the treshold of the 21st century, an intensive debate about globalisation of R&D and technology markets is of cucial importance. Globalisation will carry on changing the framework for company strategies and subsequently for public policies ...
Reger, G. +2 more
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Наукові праці Лісівничої академії наук України, 2018 Restoration of territories disturbed as a result of mining is a “hot topic” on a global scale. Ukraine is rich in mineral resources, the development of which inevitably leads to the disruption of existing ecosystems.
Sergii Kovalevskii +4 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Unintended consequences of development interventions: a case of diarrhoeal diseases, Ruhiira, Uganda
, 2012 The present article conducts a cross-sectoral analysis of development interventions in order to identify unintended consequences resulting in increased risk of acquisition of diarrhoeal diseases.
Bergstrøm, Cassandra E. +1 more
core +1 more source