Results 121 to 130 of about 1,776,675 (371)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Art and environment as media for ecosustainability, ethics and aesthetics

open access: yesConservation Science in Cultural Heritage, 2012
“Art, both in a strict sense, but also in a broader sense, that is to say environmental and cultural heritage – considering, as it correctly should be, the environment with its individual compartments of air, soil and water – is indissolubly linked to ...
Salvatore Lorusso, Angela Braida
doaj   +1 more source

Conservation and the genetics of populations

open access: yes, 2006
Authors of Guest Boxes. Preface. List of Symbols. PART I: INTRODUCTION. 1 Introduction. 1.1 Genetics and conservation. 1.2 What should we conserve?. 1.3 How should we conserve biodiversity?. 1.4 Applications of genetics to conservation. Guest Box 1 by L.
F. Allendorf, G. Luikart
semanticscholar   +1 more source

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

On the different types of global and local conservation laws for partial differential equations in three spatial dimensions: review and recent developments [PDF]

open access: yesInternational Journal Nonlinear Mechanics 126 (2020), 10359, 2018
For systems of partial differential equations in three spatial dimensions, dynamical conservation laws holding on volumes, surfaces, and curves, as well as topological conservation laws holding on surfaces and curves, are studied in a unified framework. Both global and local formulations of these different conservation laws are discussed, including the
arxiv  

Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays

open access: yesFEBS Open Bio, EarlyView.
We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques   +5 more
wiley   +1 more source

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