Results 71 to 80 of about 729,067 (269)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A Conservative future ? Youth and the Conservative Party

Observatoire de la société britannique, 2007
Lors des élections législatives britanniques de 2005, environ 28 % des 18-24 ans qui ont participé au scrutin ont voté pour le Parti conservateur, contre 38 % pour le parti travailliste et 26 % pour le parti des libéraux démocrates. Clairement, le Parti conservateur n’était pas le premier choix de la plupart des jeunes électeurs, tout comme lors des ...
openaire   +2 more sources

A note from the restoration world: the Raffaello completed?

Conservation Science in Cultural Heritage, 2002
History of a restoration work that had opened the way to a new, fascinating attribution hypothesis for a drawing that was considered a Giulio Romano’s work and today it is considered a Raffaello’s work, with a subsequently partial intervention of his ...
Pietro Livi
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Chemistry: our Life, our Future

Conservation Science in Cultural Heritage, 2017
In this note we look at a number of aspects relating to chemistry that have had a strong impact on the future of humanity. In particular, some technological innovations have been examined which have had a strong impact on daily life in general; the role ...
Ferruccio Trifirò
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Conserver la conservation

Bifurcation/s
Le conservatisme est une manière de concevoir la politique à partir d’une vision figée des rapports sociaux et s’impose comme un mode de gouvernement qui assigne à résidence les identités sociales. Cependant, cette option politique n’est pas sans soulever quelques antilogies dès lors qu’on le confronte à la question écologique - entendue ici comme le ...
openaire   +2 more sources

Culture, not culturalism: the journal “Conservation Science in Cultural Heritage”

Conservation Science in Cultural Heritage, 2022
Cosimo Damiano Fonseca
doaj   +1 more source