Results 141 to 150 of about 22,400 (311)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

An Investigation into the importance of propagule provenance in restoration ecology

There is increasing concern among restoration ecologists that using non-local propagules in revegetation schemes may influence the success of grassland restoration.
Smith, Barbara Maria
core  

Hiptage yangshuoensis (Malpighiaceae), a new species on karst hills close to Lijiang River, Guangxi, China, based on molecular and morphological data

Ecology and Evolution
Hiptage yangshuoensis K.Tan & K.S.Nguyen, a new species of Hiptage collected from a karst cliff close to the Lijiang River, Northeast of Guangxi Zhuang Autonomous Region, China, is described and illustrated based on molecular and morphological data ...
Ren‐Fen Wang, Yao Ning, Xiao‐Juan Li, Ke Tan, Khang Sinh Nguyen   +4 more
doaj   +1 more source

Nitrogen and phosphorus addition interactively affected the abundance of soil nematodes in a Tibetan alpine meadow

Global Ecology and Conservation
There has been a significant increase in atmospheric nitrogen (N) and phosphorus (P) deposition since the Industrial Revolution, profoundly affecting the structure and function of terrestrial ecosystems.
Runhao Liu, Jingwei Guo, Mingli Wei, Jiarui Feng, Zhenyu Zhu, Siying Liu, Cancan Zhao, Zhongling Yang, Guoyong Li, Kai Gao, Yinzhan Liu   +10 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Resilience of New Zealand indigenous forest fragments to impacts of livestock and pest mammals

, 2011
A number of factors have combined to diminish ecosystem integrity in New Zealand indigenous lowland forest fragments surrounded by intensively grazed pasture.
King, Carolyn M., Burns, Bruce, Innes, John G., Didham, Raphael, Dodd, Mike, Smale, Mark, Watts, Corinne, Barker, Gary M.   +7 more
core  

Health and wellbeing benefits of conservation in New Zealand [PDF]

, 2013
: Despite a long-held popular belief that nature is ‘healthy’ for people, exactly how or even whether this is true has only recently been subject to scientific scrutiny. This report reviews key literature relevant to the relationship between conservation
Paul Blaschke
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Evolutionary conservation genetics of invasive and endemic parrots [PDF]

, 2015
The world is now thought to have entered into a sixth mass extinction event, which unlike previous mass extinctions, is entirely driven by human impacts.
Jackson, Hazel Anne
core  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source