Results 91 to 100 of about 381,080 (315)

Low rates of hybridization between European wildcats and domestic cats in a human‐dominated landscape

Ecology and Evolution, 2018
Hybridization between wild species and their domestic congeners is considered a major threat for wildlife conservation. Genetic integrity of the European wildcat, for instance, is a concern as they are outnumbered by domestic cats by several orders of ...
Katharina Steyer, Annika Tiesmeyer, Violeta Muñoz‐Fuentes, Carsten Nowak   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Unraveling the Complexity of the Ne/Nc Ratio for Conservation of Large and Widespread Pelagic Fish Species: Current Status and Challenges

Evolutionary Applications
Estimating and understanding the ratio between effective population size (Ne) and census population size (Nc) are pivotal in the conservation of large marine pelagic fish species, including bony fish such as tunas and cartilaginous fish such as sharks ...
Chrystelle Delord, Sophie Arnaud‐Haond, Agostino Leone, Jonathan Rolland, Natacha Nikolic   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Genetics and conservation biology

Comptes Rendus. Biologies, 2003
Conservation genetics encompasses genetic management of small populations, resolution of taxonomic uncertainties and management units, and the use of molecular genetic analyses in forensics and to understanding species' biology. The role of genetic factors in extinctions of wild populations has been controversial, but evidence now shows that they make ...
openaire   +2 more sources

Conservation genetics of the yellow-bellied toad (Bombina variegata): population structure, genetic diversity and landscape effects in an endangered amphibian [PDF]

, 2021
Heike Pröhl, Jana Auffarth, Tjard Bergmann, Holger Buschmann, Niko Balkenhol   +4 more
openalex   +1 more source

Mitochondrial phylogeography and demographic history of the Vicuña: implications for conservation [PDF]

, 2007
The vicuña (Vicugna vicugna; Miller, 1924) is a conservation success story, having recovered from near extinction in the 1960s to current population levels estimated at 275 000.
A Prieto, A Spotorno, AN Menegaz, AR Templeton, BJ MacFadden, C Ammann, C Kull, C S Casey, CB Koford, CM Clapperton, D Hoces, D Posada, DL Swofford, F Tajima, GA Watterson, GI Molina, GS Miller Jr, H Jungius, H Schaschl, HF Stanley, HG Nami, IR Grimwood, J C Marín, J C Wheeler, J Olazabal, J Rodriguez, J Rozas, J Thornback, JA Harrison, JC Wheeler, JC Wheeler, JC Wheeler, JC Wheeler, JD Clayton, K Yaya, KA Tolley, L Excoffier, L Excoffier, M Clement, M Kadwell, M Kadwell, M Ubilla, M W Bruford, MC Norambuena, MK Kuhner, ML Maté, MW Bruford, N Ray, O Thomas, OS Paulo, R Hoffstetter, R Rosadio, RE Palma, RJ Sarno, S Schneider, SD Webb, T Tserenbataa, TD Dillehay, WP Madison, YX Fu, Z Lin   +60 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Phylogeography of New Zealand’s coastal benthos [PDF]

, 2009
During the past 30 years, 42 molecular studies have been undertaken in New Zealand to examine the phylogeography of coastal benthic invertebrates and plants. Here, we identify generalities and/or patterns that have emerged from this research and consider
Hogg, Ian D., Lundquist, Carolyn J., Pilditch, Conrad A., Ross, Philip M.   +3 more
core   +1 more source