Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Sex or poison? Genetic pest management in the 21st century
BMC Biology, 2023 Advances in genetic technology have made possible a suite of genetics-based methods for controlling pests of importance to public health, agriculture and conservation.
Luke Alphey
doaj +1 more source
Loss of genetic diversity and increased genetic structuring in response to forest area reduction in a ground dwelling insect: a case study of the flightless carabid beetle Carabus problematicus (Coleoptera, Carabidae) [PDF]
, 2012 1.Old growth temperate broadleaved forests are characterised by a large proportion of forest specialists with low dispersal capability. Hence, species bound to this habitat are expected to be highly susceptible to the effects of decreasing patch size and
Desender, Konjev +6 more
core +2 more sources
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
Conservation evo-devo: preserving biodiversity by understanding its origins [PDF]
, 2017 Unprecedented rates of species extinction increase the urgency for effective conservation biology management practices. Thus, any improvements in practice are vital and we suggest that conservation can be enhanced through recent advances in evolutionary ...
Adams, Colin E. +3 more
core +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
BMC Genomics, 2021 Background Understanding the processes that lead to hybridization of wolves and dogs is of scientific and management importance, particularly over large geographical scales, as wolves can disperse great distances.
Jenni Harmoinen +19 more
doaj +1 more source
Conservation of Lactuca watsoniana Trelease, an Azorean priority species : phylogenetics, population genetics and propagation [PDF]
, 2018 Tese de Doutoramento, Biologia, 28 de maio de 2018, Universidade dos Açores.Lactuca watsoniana Trel., é uma herbácea perene, endémica do Arquipélago dos Açores.
Dias, Elisabete Furtado
core
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Development of innovative tools for understanding marine biodiversity and assessing good environmental status: the EU project DEVOTES [PDF]
, 2012 AZTI-Tecnalia organized the XVII edition of SIEBM – Iberian Symposium on Marine Biology Studies, in Donostia – San Sebastián, from 11th to 14th September 2012.
Borja, Àngel
core +1 more source