Results 101 to 110 of about 145,138 (286)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Conservation Genetics of Taxus contorta_Pakistan

, 2014
Conservation Genetics of Taxus ...
Michael Möller (128920), Lian-Ming Gao (128924), Möller, Michael, Amin Shah (3290193), Li, De-Zhu, Gao, Lian-Ming, Ram C. Poudel (128919), Poudel, Ram C., De-Zhu Li (128942), Shah, Amin   +9 more
core   +1 more source

The conservation genetics juggling act: integrating genetics and ecology, science and policy

Evolutionary Applications, 2015
The field of conservation genetics, when properly implemented, is a constant juggling act integrating molecular genetics, ecology, and demography with applied aspects concerning managing declining species or implementing conservation laws and policies ...
S. Haig, Mark P. Miller, Renee Bellinger, Hope M Draheim, Dacey M. Mercer, T. D. Mullins   +5 more
semanticscholar   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Noninvasive population genetics: a review of sample source, diet, fragment length and microsatellite motif effects on amplification success and genotyping error rates.

, 2007
International audienceNoninvasive population genetics has found many applications in ecology and conservation biology. However, the technical difficulties inherent to the analysis of low quantities of DNA generally tend to limit the efficiency of this ...
Petit, E, Ménard, Nelly, Ménard, N, Broquet, Thomas, Petit, Eric, Broquet, T   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Editorial: Genetics applied to mammal conservation

Frontiers in Genetics, 2022
Fernando Marques Quintela, Carla Martins Lopes, Gislene Lopes Gonçalves   +2 more
doaj   +1 more source

Genetic evidence of population structuring in the neotropical freshwater fish Brycon hilarii (Valenciennes, 1850)

Brazilian Journal of Biology
Brycon hilarii is a migratory fish widely distributed throughout the Paraguay River Basin. It is appreciated in sport fishing and for its superior meat quality. It is also the main species for tourist attraction in the Bonito region (State of Mato Grosso
A Sanches, PM. Galetti Jr
doaj   +1 more source

ConservaGen software: A useful tool for genetic conservation of germplasm

Crop Breeding and Applied Biotechnology, 2021
ConservaGen software can assist germplasm conservation projects in terms of population genetics. It can be used for both in situ and ex situ germplasm conservation and can generate parameters to assist in decision-making in these projects. ConservaGen is
Andrei Caíque Pires Nunes
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source