Results 121 to 130 of about 145,138 (286)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Economic Evaluation and Biodiversity Conservation of Animal Genetic Resources [PDF]

Rapidly declining biodiversity has made international and national policies focus on the question of how best to protect genetic resources. Loss of biodiversity does not only concern wildlife, but equally affects agriculturally used species.
Bertaglia, Marco, Roosen, Jutta, Fadlaoui, Aziz   +2 more
core  

Local adaptation and genetics of acid-stress tolerance in the moor frog, Rana arvalis

, 2004
As potential to adapt to environmental stress can be essential for population persistence, knowledge on the genetic architecture of local adaptation is important for conservation genetics.
Räsänen, Katja,, Söderman, Fredrik, Laurila, Anssi, Söderman, Fredrik,, Merilä, Juha, Räsänen, Katja, Laurila, Anssi,, O'Hara, Robert   +7 more
core   +1 more source

Genetic load and viability of a future restored northern white rhino population

Evolutionary Applications
As biodiversity loss outpaces recovery, conservationists are increasingly turning to novel tools for preventing extinction, including cloning and in vitro gametogenesis of biobanked cells.
Aryn P. Wilder, Cynthia C. Steiner, Sarah Hendricks, Benjamin C. Haller, Chang Kim, Marisa L. Korody, Oliver A. Ryder   +6 more
doaj   +1 more source

Conservation Genetics of the Cheetah: Genetic History and Implications for Conservation [PDF]

Cheetahs: Biology and Conservation, 2018
From allozymes in 1983 to whole genomes in 2015, genetic studies of the cheetah have been extensive. In this chapter we provide an overview of the available literature.
Schmidt-Küntzel A, Dalton D, Menotti-Raymond M, Fabiano E, Charruau P, Johnson W, Sommer S, Marker L, Kotzé A, O’Brien S.   +9 more
europepmc   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A paired comparison of scat‐collecting versus scat‐swabbing methods for noninvasive recovery of mesocarnivore DNA from an arid environment

Wildlife Society Bulletin, 2015
Noninvasive DNA sampling from scats can provide powerful tools for wildlife research depending in large part on how scats are collected in the field. Preservation of scat in 95–100% ethanol can be highly effective, but not always practical.
Kathleen A. Miles, Michelle N. Holtz, Zachary T. Lounsberry, Benjamin N. Sacks   +3 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Landscape genetics of highly disturbed arable systems : insights gained from investigating a small mammal species

, 2015
A large proportion of the earth’s surface is dedicated to food production, and agriculture is widely acknowledged to influence local biodiversity via habitat loss and degradation.
Wilson, Amanda
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source