Results 141 to 150 of about 145,138 (286)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Conservation Genetics lab

, 2015
Conservation Genetics lab at Abernathy Fish Technology Center.
Hagerty, Ryan, USFWS
core  

Introduction to Conservation Genetics

, 2001
L. Lim
semanticscholar   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Dynamics of genetic diversity and population structure of Eucalyptus urophylla from Indonesian Islands using SNP data

Eucalyptus urophylla is one of the most economically important species in the world due to its wood quality and tolerance to water stress. Understanding the genetic composition at the population level of this species is essential for the sustainable and ...
Benatti, Thiago Romanos, Beerli, Peter, Rosa, João Ricardo Bachega Feijó, Oda, Shinitiro, Fernandes, Aline Cristina Miranda, Tambarussi, Evandro Vagner [UNESP], de Silva, Dandara Yasmim Bonfim Oliveira [UNESP], de Matos, Jose Wilacildo, de Souza, Izabel Christina Gava, Nunes, Maria Paula Barion Alves [UNESP]   +9 more
core   +1 more source

Implications of molecular systematic analyses on the conservation of rare and threatened taxa : contrasting examples from Malvaceae

, 2005
Systematic research provides essential evidence for setting conservation priorities for rare and endangered taxa. Phylogenetic analyses can identify cryptic, genetically distinct lineages as well as actively interbreeding, and hence, non-distinctive ...
Andreasen, Katarina,
core   +1 more source

Conservation Genetics of the Loggerhead Sea Turtle, Caretta caretta, from the Central Mediterranean: An Insight into the Species' Reproductive Behaviour in Maltese Waters. [PDF]

Animals (Basel), 2023
Vella A, Vella N.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Editorial: Population genetics and conservation of aquatic species

Frontiers in Genetics, 2023
Shaokui Yi, Cong Zeng, Yanhe Li, Narongrit Muangmai   +3 more
doaj   +1 more source