Results 101 to 110 of about 381,080 (315)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Conservation genetics of Amazonian plants: a scientometric approach [PDF]

, 2023
Joellyson Lucas da Conceição dos SANTOS
openalex  

Mitogenome information in cattle breeding and conservation genetics: Developments and possibilities of the SNP chip

, 2023
Vladimir Brajković, Dalibor Hršak, Ljubomir Bradic, K. Turkalj, Dinko Novosel, Strahil Ristov, Paolo Ajmone‐Marsan, Licia Colli, Vlatka Čubrić-Ćurik, Johann Sölkner, Ino Čurik   +10 more
openalex   +1 more source

Editorial: Genetics applied to mammal conservation

Frontiers in Genetics, 2022
Fernando Marques Quintela, Carla Martins Lopes, Gislene Lopes Gonçalves   +2 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

ARCAD- Agropolis Resource Center for Crop Conservation, Adaptation and Diversity : a new open multi-function platform devoted to agrobiodiversity. Objectives and challenges [PDF]

, 2009
ARCAD, short for Agropolis Resource Center for Crop Conservation, Adaptation and Diversity, is an initiative supported by Agropolis Fondation, the Region Languedoc Roussillon (France) and several French research institutions.
Labouisse, Jean-Pierre, Pham, Jean Louis
core  

Genetic evidence of population structuring in the neotropical freshwater fish Brycon hilarii (Valenciennes, 1850)

Brazilian Journal of Biology
Brycon hilarii is a migratory fish widely distributed throughout the Paraguay River Basin. It is appreciated in sport fishing and for its superior meat quality. It is also the main species for tourist attraction in the Bonito region (State of Mato Grosso
A Sanches, PM. Galetti Jr
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Adaptive evolution of molecular phenotypes

, 2014
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad, Chernyak V Y, Crow J F, Falconer D S, Fisher R, Lynch M, Lynch M, Lynch M, Michael Lässig, Muller H J, Neher R A, Nourmohammad A, Nourmohammad A, Torsten Held   +13 more
core   +1 more source

Isolation and characterization of 15 SSR loci for the endangered European tetraploid species Gladiolus palustris (Iridaceae)

Applications in Plant Sciences, 2019
Premise Gladiolus palustris (Iridaceae) is an endangered European perennial tetraploid herb with special conservation interest in the European Union.
Tamás Malkócs, Shyryn Almerekova, Judit Bereczki, Judit Cservenka, Emese Meglécz, Gábor Sramkó   +5 more
doaj   +1 more source