Results 191 to 200 of about 1,527,554 (269)

Conservation genomics of a threatened subtropical Rhododendron species highlights the distinct conservation actions required in marginal and admixed populations. [PDF]

Plant J
Chang Y, Zhang R, Liu Y, Liu Y, Tao L, Liu D, Ma Y, Sun W.   +7 more
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Application of Conservation Genomics to Investigate the Role of Pathogens on the Migration of Sea-Run Brown Trout (Salmo trutta). [PDF]

J Fish Dis
Lennox RJ, Eldøy SH, Schulze AD, Miller KM, Isaksen TE, Davidsen JG, Nilsen CI, Dahlmo LS, Vollset KW.   +8 more
europepmc   +1 more source

Conservation Genomics of a Threatened Rhododendron: Contrasting Patterns of Population Structure Revealed From Neutral and Selected SNPs. [PDF]

Front Genet, 2020
Liu D, Zhang L, Wang J, Ma Y.
europepmc   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Corrigendum to "Conservation genomics provides insights into genetic resilience and adaptation of the endangered Chinese hazelnut, <i>Corylus chinensis</i>" [Plant Divers. 46 (3) (2024) 294-308]. [PDF]

Plant Divers
Yang Z, Liang L, Xiang W, Wang L, Ma Q, Wang Z.   +5 more
europepmc   +1 more source

Integrative Conservation Genomics

Conservation genomics -- the application of whole-genome sequencing, population genomic analysis, and landscapegenomics to inform conservation management of threatened species and populations -- has transformed conservationgenetics from a field constrained by a few dozen microsatellite markers to one capable of resolving population structureat the SNP ...
Helena Popescu, Nina Garcia, Ivan Bianchi   +2 more
openaire   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics. [PDF]

Sci Rep
Lok S, Lau TNH, Trost B, Tong AHY, Paton T, Wintle RF, Engstrom MD, Gunn A, Scherer SW.   +8 more
europepmc   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source