Results 41 to 50 of about 1,527,554 (269)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Oz Mammals Genomics initiative: developing genomic resources for mammal conservation at a continental scale

, 2018
The Australo-Papuan region has a unique mammal fauna, which faces unique threats and poses important evolutionary and ecological questions. Genomics has great potential to advance our understanding of the region's mammals and their conservation.
The Oz Mammals Genomics Consortium, Palmer, Stephanie, Rebecca Johnson, Anna Fitzgerald, Young, Andrew, Fitzgerald, Anna, Oz Mammals Genomics Consortium, The, Stephanie Palmer, Anna MacDonald, MacDonald, Anna, Deakin, JanineJanine, Moritz, Craig, Byrne, Margaret, Margaret Byrne, Craig Moritz, Johnson, Rebecca, JanineJanine Deakin, Andrew Young, Eldridge, Mark, Mark Eldridge   +19 more
core   +1 more source

Artificial Nesting Hills Promote Wild Bees in Agricultural Landscapes

Insects, 2022
The availability of nesting resources influences the persistence and survival of bee communities. Although a positive effect of artificial nesting structures has frequently been shown for aboveground cavity-nesting wild bees, studies on below ground ...
Ulrich Neumüller, Hannah Burger, Antonia V. Mayr, Sebastian Hopfenmüller, Sabrina Krausch, Nadine Herwig, Ronald Burger, Olaf Diestelhorst, Katrin Emmerich, Mare Haider, Manuel Kiefer, Jonas Konicek, Johann-Christoph Kornmilch, Marina Moser, Christoph Saure, Arno Schanowski, Erwin Scheuchl, Julia Sing, Max Wagner, Julia Witter, Hans R. Schwenninger, Manfred Ayasse   +21 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis [PDF]

, 2009
BACKGROUND: The availability of the complete chicken (Gallus gallus) genome sequence as well as a large number of chicken probes for fluorescent in-situ hybridization (FISH) and microarray resources facilitate comparative genomic studies between ...
Ioannou, D., Völker, Martin, Robertson, Lindsay, Langley, Elizabeth J, Robertson, Lindsay BW, Tempest, Helen G, Skinner, Benjamin M., Tempest, Helen G., Tempest, H., Völker, M., Skinner, M., Crooijmans, Richard P.M.A., Hall, Anthony D, Fowler, K., Skinner, Benjamin M, Robertson, L.B., Crooijmans, Richard PMA, Skinner, B., Fowler, Katie E., Griffin, Darren K, Langley, E.J., Crooijmans, R.P.M.A., Griffin, D., Hall, A., Robertson, L., Tempest, H.G., Ioannou, Dimitris, Fowler, K.E., Crooijmans, R., Griffin, Darren K., Langley, E.   +30 more
core   +1 more source

Novel antimicrobial peptides and peptide-microbiome crosstalk in Appalachian salamander skin

npj Biofilms and Microbiomes
Using multi-omics tools, we discovered new antimicrobial peptides (AMPs) and examined AMP-microbial interactions in three Appalachian salamander species (Plethodon cinereus, Eurycea bislineata and Notophthalmus viridescens).
Carly R. Muletz-Wolz, Julian Urrutia-Carter, Owen Osborne, Steve Kutos, Jose Meneses Montano, Joseph D. Madison, Brian Gratwicke, Ratanachat Racharaks, Norma E. Roncal, Randall R. Jimenez, Amy Ellison, Timothy P. Cleland   +11 more
doaj   +1 more source

Changes in biodiversity drive trypanosome infections of wildlife in Panama

One Health
Understanding how anthropogenic disturbances impact biodiversity and zoonotic disease transmission is critical for safeguarding human and animal health. In Panama, we studied the effects of these disturbances on wildlife populations and Trypanosoma cruzi
Magdalena Meyer, Georg Eibner, Alexander Christoph Heni, Kerstin Wilhelm, Simone Sommer   +4 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Natural variability of trace-amine associated receptors in wild meerkats

Frontiers in Zoology
Background The study of olfaction as a sensory modality has been relatively neglected in comparison to other sensory cues, particularly in wildlife research.
Johannes Fähnle, Kerstin Wilhelm, Benedikt Wiese, Marta Manser, Tim Clutton-Brock, Simone Sommer, Nadine Müller-Klein   +6 more
doaj   +1 more source