Results 181 to 190 of about 1,065,128 (300)

Animal cultures matter for conservation, but also to animals. [PDF]

Learn Behav
Fitzpatrick S, Andrews K.
europepmc   +1 more source

CONSERVATION OF NATURAL RESOURCES* [PDF]

Nature, 1941
openaire   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Fishers' Perceptions of Fishing Dynamics and Socio-environmental Threats in Coastal Protected Areas of Northeastern Brazil. [PDF]

Environ Manage
de Oliveira YCBB, Lopes PFM, de Oliveira TA, Vidal DG, Alves F, Rosa MDRT, Mourão JDS.   +6 more
europepmc   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Harnessing Deep Learning in Searching Wild Relatives of Domestic Animals. [PDF]

Mol Ecol Resour
Cai ZF, Liu B, Yin TT, Ma C, Han ZT, Gu LH, Zhang C, Wu F, Liu LS, Shi X, Wang XQ, Wu RN, Xie LZ, Bai Y, Zhang YC, Zhang SR, Gu LJ, Wang MS, Xie GL, Cheng WK, Lu JG, Luo Y, Li SB, Ashari H, Zein MSA, Han JL, Singchat W, Srikulnath K, Zhang YP, Peng MS.   +29 more
europepmc   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Balancing environmental benefits and accessibility for national park buffer zones in China. [PDF]

Sci Rep
Cai Y, Ma Y, Wu Y, Ye C.
europepmc   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

From Glacial Refugia to Future Shifts: Unraveling the Spatiotemporal Dynamics of Endangered <i>Acer sutchuenense</i> Franch. Under Climate Change. [PDF]

Biology (Basel)
Xia X, Yang X, Li S, Xiang W, He L, Luo Z.   +5 more
europepmc   +1 more source