Results 81 to 90 of about 784,465 (187)

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

Regional Water Planning in South Carolina : Developing a framework for water planning on a basinwide scale [PDF]

, 2012
This Powerpoint presentation discusses the planning process for water availability in South Carolina focusing on regional ...
South Carolina Department of Natural Resources, Land, Water and Conservation Division
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LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

AGENDA: US-Mexico Negotiations on Improved Colorado River Management: An Update [PDF]

, 2010
The United States and Mexico are currently negotiating an international accord on a variety of Colorado River water matters, including the prospects for new water projects, conservation efforts, and operational improvements.
Colorado Water Conservation Board, University of Colorado Boulder. Natural Resources Law Center, Western Water Policy Program   +2 more
core   +1 more source

AlphaFold‐Guided Bespoke Gene Editing Enhances Field‐Grown Soybean Oil Contents

Advanced Science, EarlyView.
An AlphaFold‐guided method is developed to functionally optimize soybean sugar transporters and achieve bespoke gene editing of GmSWEET10a/b to improve oil content in an elite soybean cultivar in multi‐year, multi‐site field trials. The combination of AI‐guided protein design and gene editing may unlock a huge potential to improve the genetic trait de ...
Jie Wang, Li Zhang, Shoudong Wang, Xin Wang, Suning Li, Pingping Gong, Mengyan Bai, Arnav Paul, Nathan Tvedt, Hengrui Ren, Maoxiang Yang, Zhihui Zhang, Shaodong Zhou, Jiayi Sun, Xianjin Wu, Huaqin Kuang, Zhenghua Du, Yonghui Dong, Xiaolei Shi, Meina Li, Diwakar Shukla, Long Yan, Yuefeng Guan   +22 more
wiley   +1 more source

West Virginia Food Dessert Summit Handout [PDF]

, 2019
Handout from the 2019 West Virginia Food Desert ...
USDA Natural Resources Conservation Service, West Virginia University Davis College of Agriculture, Natural Resources and Design, West Virginia University Extension Service, West Virginia University School of Public Health, WVU Foundation   +4 more
core   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Property rights and wildlife utilisation : generating incentives for conservation and economic development : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Economics at Massey University [PDF]

, 1999
The accelerating depletion of natural resources (biological diversity) range from degraded ecosystems, endangered species, and loss of genetic resources. This depletion has raised concern over future human economic welfare among other things Conservation
Bullen, Philip
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Natural Toolbox–Chemical Engineering Aspect and High‐Value Applications of Janus Cellulose Nanomaterials

Advanced Science, EarlyView.
The Tai Ji symbol from China represents the co‐existence of two opposite substances, similar to quantum entanglement. The term Janus comes from ancient Roman religion and mythology. Janus, the god of beginnings, transitions, etc., has two faces, symbolizing duality. Janus cellulose nanomaterials show structural duality.
Yu Zhao, Shengjie Wang, Zongchen Wei, Shiming Qiu, Guofu Zhou, Jr‐Hau He, Xuezhu Xu   +6 more
wiley   +1 more source

Dynamic and Stable Core Microbiota Assist Plants in Enriching Selenium and Reducing Cadmium Absorption

Advanced Science, EarlyView.
During different developmental stages of plants in natural Se–Cd coexisting soils, there is a group of rhizosphere microorganisms with highly dynamic abundance. The abundance variation of these microorganisms is strongly positively correlated with available Se and strongly negatively correlated with available Cd.
Zheng Lei, Hua Zhang, Wenju Liu, Jiandong Sheng, Huan Zhang, Yin Wang, Yanni Tang, Huaxing Wang, Cuicui Ding, Wanqi Qiao, Yonghui Zhu, Guoyin Yang, Yihan Zhang, Zhuoyi Liu, Nanyu Zhou, Chengxiao Hu, Xiaohu Zhao   +16 more
wiley   +1 more source