Results 181 to 190 of about 62,065 (264)

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Strengths and complementarity of systematic conservation planning and Key Biodiversity Area approaches for spatial planning. [PDF]

Conserv Biol
Plumptre A, Hayes J, Baisero D, Rose R, Holness S, von Staden L, Smith RJ.   +6 more
europepmc   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

From Ecological Niche to Conservation Planning; Climate-Driven Range Dynamics of <i>Ephedra intermedia</i> in Central Asia. [PDF]

Ecol Evol
Waheed M, Arshad F, Sadia S, Fonge BA, Al-Andal A, Jabeen A, Dilshad S.   +6 more
europepmc   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Megabenthic Diversity Patterns on a Seamount in the Philippine Sea: Implications for Conservation Planning on the Kyushu-Palau Ridge. [PDF]

Ecol Evol
Lu X, Shen C, Yang C, Xu W, Yang J, Wang C, Sun D.   +6 more
europepmc   +1 more source

Architected Spatially Deterministic Multiscale Phase Segregation in Block Copolymer Composites for Augmented Radiative Cooling

Advanced Science, EarlyView.
Multiscale phase segregation in block copolymers enables spatially deterministic structuring from molecular to macroscopic scales, decoupling solar scattering and infrared emission for augmented radiative cooling. ABSTRACT Passive radiative cooling, which reflects solar irradiation while emitting heat through the atmospheric window, provides a ...
Mingxin Feng, Feiyang Zhou, Haoran Cai, Wenchao Zhai, Shuangjiang Feng, Yanmei Liu, Xiaohai Bu, Man He, Dudong Feng, Shuang Liang, Yuming Zhou   +10 more
wiley   +1 more source

Three-dimensional conservation planning of fish biodiversity metrics to achieve the deep-sea 30×30 conservation target. [PDF]

Conserv Biol
Mathon L, Baletaud F, Lebourges-Dhaussy A, Lecellier G, Menkes C, Bachelier C, Bonneville C, Dejean T, Dumas M, Fiat S, Grelet J, Habasque J, Manel S, Mannocci L, Mouillot D, Peran M, Roudaut G, Sidobre C, Varillon D, Vigliola L.   +19 more
europepmc   +1 more source

cis‐Carboxylate Enhancement of Mn(III)‐OH Hydrogen Atom Abstraction through PCET Thermodynamics

Advanced Science, EarlyView.
ABSTRACT Manganese(III)‐hydroxo intermediates are proposed as key hydrogen atom abstraction (HAA) species in manganese‐dependent enzymes, yet how first‐sphere carboxylate ligands control their proton‐coupled electron transfer (PCET) thermodynamics remains poorly understood.
Yuri Lee, Yujin Sim, Sehun An, Kyung‐Bin Cho, Jaeheung Cho   +4 more
wiley   +1 more source

Assessing habitat connectivity of rare species to inform urban conservation planning. [PDF]

Ecol Evol
McCluskey EM, Kuzma FC, Enander HD, Cole-Wick A, Coury M, Cuthrell DL, Johnson C, Kelso M, Lee YM, Methner D, Rowe L, Swinehart A, Moore JA.   +12 more
europepmc   +1 more source