Results 91 to 100 of about 56,540 (246)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The long‐term impacts of Marine Protected Areas on fish catch and socioeconomic development in Tanzania

Conservation Letters
Marine Protected Areas (MPAs) are a cornerstone of marine conservation efforts, with the potential to protect biodiversity and provide socioeconomic benefits.
Sébastien Desbureaux, Julia Girard, Alicia Dalongeville, Rodolphe Devillers, David Mouillot, Narriman Jiddawi, Loic Sanchez, Laure Velez, Laetitia Mathon, Antoine Leblois   +9 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Mapping social conflicts to enhance the integrated management of white‐tailed deer (Odocoileus virginianus)

Conservation Science and Practice
Understanding the social feasibility of wildlife conservation approaches is essential to reducing social conflicts over wildlife and public backlash toward wildlife agencies and organizations.
Taylor R. Stinchcomb, Zhao Ma, Robert K. Swihart, Joe N. Caudell, Zoe Nyssa, Carly C. Sponarski   +5 more
doaj   +1 more source

Visioning future treescapes in upland landscapes: using deliberative processes to understand values and land-use preferences of local stakeholders

Ecosystems and People
UK environmental policy places an increasing emphasis on large-scale land-use change, with tree-planting objectives set to contribute towards meeting legislated climate and environmental targets.
Alix Syder, Susan Baker, Euan Bowditch, Sheena Carlisle, Tom Finch, Melissa Minter, Natasha Constant   +6 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Five critical questions we should ask of rewilding projects—And that social science can help us answer

People and Nature
Engaging conservation decision‐making with critical aspects of social science can enhance the equitability of conservation practice by recentring issues of social and environmental justice.
Emma Cary, Karen Jones, Virginia Thomas, Signe Brieghel, Ana Payo Payo, Flurina M. Wartmann   +5 more
doaj   +1 more source

‘Race the Wild’: Encountering Non-human Life Through the Gamification of Wildlife Movement

Conservation & Society
Digital technologies are becoming increasingly important in human engagements with the natural world. It has been suggested that digital games could contribute to the work of biodiversity conservation organisations, mediating human understanding of, and ...
Chris Sandbrook, Emma Tait, William M. Adams   +2 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source