Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
African Forest elephants persist in Guinea-Bissau but require an emergency conservation plan
OryxThe status of the forest elephant Loxodonta cyclotis in Guinea-Bissau has been in doubt since the last assessment in 2006. In 2020–2022 we carried out field surveys to update the species' status. We found elephant signs within an area of c.
Luís Palma +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Impact of Spatial Heterogeneity in Land Use Practices and Aquifer Characteristics on Groundwater Conservation Policy Cost [PDF]
Estimation of agricultural policy cost for a given level of groundwater conservation requires the establishment of an accurate baseline condition. This is especially critical when the benefits and cost of any conservation program are generally estimated ...
Barbato, Lucia S. +6 more
core +1 more source
Object identification and characterization with hyperspectral imagery to identify structure and function of Natura 2000 habitats [PDF]
, 2010 Habitat monitoring of designated areas under the EU Habitats Directive requires every 6 years information on area, range, structure and function for the protected (Annex I) habitat types.
Delalieux, S. +7 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Shellfish Outreach Project [PDF]
, 2003 The purpose of the Shellfish Outreach project was to disseminate educational information to the greater seacoast community on the value of aquaculture, status and opportunities in shellfishing, and hands-on local conservation strategies in an exciting ...
Smith, Dyanna I
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Dactylorhiza kalopissii (Liliopsida: Orchidacea) in Bulgaria: Distribution and conservation status [PDF]
, 2019 Antoaneta S. Petrova +2 more
openalex +1 more source
Ichthyofauna of the Katamadari River, Bangladesh: Composition, Conservation Status and Threats
, 2022 MA Sultana +5 more
openalex +2 more sources