Results 71 to 80 of about 4,976,009 (235)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Defining conservation units with enhanced molecular tools to reveal fine scale structuring among Mediterranean green turtle rookeries

Biological Conservation, 2018
Understanding the connectivity among populations is a key research priority for species of conservation concern. Genetic tools are widely used for this purpose, but the results can be limited by the resolution of the genetic markers in relation to the ...
Phil J. Bradshaw, A. Broderick, Carlos Carreras, W. Fuller, R. Snape, Lucy I Wright, B. Godley   +6 more
semanticscholar   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Estudo do uso público e análise ambiental das trilhas em uma unidade de conservação de uso sustentável: Floresta Nacional de Ipanema, Iperó - SP Public utility study and environmental analysis of tracks at a sustainable conservation unit: Ipanema National Forest in Ipero-SP

Revista Árvore, 2008
O trabalho teve como objetivo analisar o uso público das trilhas ecoturísticas da Floresta Nacional de Ipanema. Para tanto, foram entrevistados 112 visitantes, quando se levantaram o perfil sociocultural e também suas expectativas quanto às trilhas ...
Paula Cristina de Souza, Henry Lesjak Martos   +1 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Deforestation and Forest Degradation Detection in the Brazilian Amazon: A Comparative Analysis of Two Areas and Their Conservation Units

Applied Sciences
This study analyzed land use and land cover (LULC) changes to identify the levels of deforestation and forest degradation in two locations in the Amazon rainforest and their conservation units.
Danielle Nogueira Lopes, Satoshi Tsuyuki
doaj   +1 more source

Federal Conservation Units in Brazil: The Situation of Biomes and Regions

, 2018
Federal conservation units (FCU) are areas legally established by the government, in order to meet the needs of protection and sustainable exploitation of biodiversity. A way to ensure the efficiency of public management is to systematize data. Therefore,
E. Mattar, T. Barros, B. Cunha, Joab Ferreira de Souza, Alcimone Maria Da C. e Silva   +4 more
semanticscholar   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Phylogenetic autocorrelation and evolutionary diversity of Carnivora (Mammalia) in Conservation Units of the New World

Genetics and Molecular Biology, 2004
One of the main concerns of Conservation Biology is the identification of priority areas for conservation, and the development of quantitative methods is important to achieve this task. Many phylogenetic diversity indexes and higher-taxon approaches have
Natália Mundim Tôrres, José Alexandre Felizola Diniz-Filho   +1 more
doaj   +1 more source