Results 211 to 220 of about 2,850,589 (369)

One-year follow-up of conservative and surgical treatment results for patients diagnosed with lumbar spinal stenosis. [PDF]

World J Orthop
Ayyildiz A, Yilmaz A, Erinç S, Aydin L, Ayyıldız H, Yilmaz F.   +5 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

When lymph defies benign surgery: postoperative chylous fistula. [PDF]

J Surg Case Rep
León GA, Lemarie AS, Cisneros WJ, Velasco SA, Montenegro ED, Campoverde TP.   +5 more
europepmc   +1 more source

Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”

Advanced Science, EarlyView.
This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner, Nina Claessens, Caitlin M. Maloney, Peter Claes   +3 more
wiley   +1 more source

The hybrid layer paradox: Rethinking the foundations of adhesive dentistry. [PDF]

J Conserv Dent Endod
Singh S, Chandrashekhar P.
europepmc   +1 more source

Conservative surgical treatment of the jaw cysts in children: Case study of five patients

, 2017
Gökhan Gürler, Serdar Yılmaz, Çağrı Deli̇lbaşı, Emrah Dilaver, Emir Yüzbaşıoğlu, A Patir-Munevveroglu   +5 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Is Concomitant Contralateral Arthroscopic Meniscectomy Effective in Patients Undergoing Unilateral Total Knee Replacement for Knee Osteoarthritis? [PDF]

J Clin Med
Hong KB, Yoon HK, Oh HC, Kang S, Park SH.   +4 more
europepmc   +1 more source

Treatment and outcome of placenta percreta: Primary cesarean hysterectomy versus conservative management

, 2019
Ernesto Licon, Shinya Matsuzaki, Karen N. Opara, Hiroko Machida, Lynda D. Roman, Elizabeth B. Sasso, Koji Matsuo   +6 more
openalex   +2 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source