Results 181 to 190 of about 13,525,492 (371)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Elderly patients with myocardial infarction selected for conservative or invasive treatment strategy

, 2015
Berglind Libungan, Thomas Karlsson, Per Albertsson, Johan Herlitz   +3 more
openalex   +2 more sources

Application of Ultrasonography in Conservative Treatment of Humeral Shaft Fracture in Children [PDF]

, 2021
Jun Li, Xin Tan, Xiang Li, Pan Gou, Xiaowei Yuan, Tao Liu, Mingyan Shi, Xing Liu   +7 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Conservative Treatment in Stress Urinary Incontinence-Narrative Literature Review. [PDF]

Life (Basel)
Poenaru MO, Ples L, Toma CV, Augustin FE, Sima RM, Amza M, Pacu I, Zampieri G, Diaconescu AS, Poenaru D.   +9 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Conservative Treatment of HAV-Associated Acalculous Acute Cholecystitis in an Adult: A Case Report. [PDF]

Case Rep Med
Medina-Ramirez SA, Arones-Santayana CA, Huamani EC, Diaz-Reyes N.   +3 more
europepmc   +1 more source

Improvement in Periodontitis Following Conservative Periodontal Treatment in a Type 1 Diabetic Patient

, 2015
Edmund Julian Ofilada, Cecilia Jimeno, Jerome Barrera   +2 more
openalex   +2 more sources

Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease.

Cochrane Database of Systematic Reviews, 2017
M. Kyrgiou, A. Athanasiou, I. Kalliala, M. Paraskevaidi, A. Mitra, P. Martin-Hirsch, M. Arbyn, P. Bennett, E. Paraskevaidis   +8 more
semanticscholar   +1 more source