Results 181 to 190 of about 1,211,398 (296)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Conservative Treatment With Teriparatide for Symptomatic Incomplete Atypical Femoral Fractures: A Retrospective Observational Study. [PDF]

Geriatr Orthop Surg Rehabil
Choi SH, Lee MG, Cho YJ, Chun YS, Rhyu KH.   +4 more
europepmc   +1 more source

Data‐Driven Modeling of Composition–Processing–Microstructure Relations for Recycled Aluminum Cast Alloys

Advanced Science, EarlyView.
Interpretable machine learning reveals how composition and processing govern the formation and microstructural burden of Fe‐rich intermetallic compounds in recycled Al–Si–Fe–Mn alloys. By separating morphology selection from morphology‐conditioned burden partitioning, this framework shows that identical Fe contents can yield different intermetallic ...
Jaemin Wang, Waleed Mohammed, Dierk Raabe   +2 more
wiley   +1 more source

Surgical versus conservative treatment of odontoid fractures in the elderly: A randomized controlled clinical study (SCORE). [PDF]

PLoS One
Wagner A, Albrecht C, Dittmer S, Egert-Schwender S, Kehl V, Stichling R, Klatt G, Ettinger B, Hecht N, Vajkoczy P, Wengert A, Kandziora F, von der Höh NH, Heyde CE, Hartung P, Richter M, Lenz M, Eysel P, Badke A, Blume C, Clusmann H, Walter J, Krieg S, Evangelou P, Shiban E, Dreimann M, Gembruch O, Sure U, Bettag C, Rohde V, Disch A, Bekele B, Ryang YM, Kramer A, Ringel F, Wach J, Güresir E, Meyer B, Wostrack M.   +38 more
europepmc   +1 more source

Outcomes from conservative treatment of shoulder idiopathic adhesive capsulitis and factors associated with developing contralateral disease [PDF]

, 2018
Brophy, Robert H, Lamplot, Joseph D, Lillegraven, Olivia   +2 more
core   +1 more source

Capacitive versus Faradaic Microelectrodes for Extracellular Stimulation: A Fully Coupled FEM–Hodgkin–Huxley Study of Thresholds and Current Redistribution

Advanced Electronic Materials, EarlyView.
A fully coupled FEM–HH model shows that ideally capacitive microelectrodes can achieve lower charge‐density thresholds than Faradaic contacts under current‐controlled stimulation. The advantage stems from the dynamics of surface current density on capacitive interfaces, which redirects current beneath adherent neurons.
Aleksandar Opančar, Eric Daniel Głowacki, Vedran Đerek   +2 more
wiley   +1 more source

Consumer Valuation of Meat Alternatives and Labeling Policies: A Comparative Perspective

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study investigates and compares US consumer perceptions and the impact of environmental, human health, and animal welfare information related to conventional meat on preferences for meat alternatives and labeling policies. Using the best–worst scaling method across 10 different burger alternatives, our results show that the meat burger is
Daniele Asioli, Wei Yang, Jia Han, Quoc Cuong Nguyen, Massimiliano Petracci, Rodolfo M. Nayga Jr.   +5 more
wiley   +1 more source

Propensity score-matched analysis of percutaneous endoscopic versus conservative treatment for lumbar disc herniation in high-risk octogenarians. [PDF]

Sci Rep
OuYang B, Sun H, Zhang K, Luo C, Zhang L.   +4 more
europepmc   +1 more source

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

Outcome analysis of conservative treatment of a distal radius fracture with OPTIVOhand orthosis versus plaster cast: a randomized controlled trial. [PDF]

BMC Musculoskelet Disord
Friederich M, Brunner J, Kirsch E, Stuby F, Zimmermann A, Histing T, Hemmann P.   +6 more
europepmc   +1 more source