Results 41 to 50 of about 12,319,651 (354)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Conservative treatment of facial burns

Медицинский вестник Юга России, 2020
Objective: compare the effectiveness of using a moisturizer containing antibacterial drugs of plant origin with a water-soluble ointment that includes the antibiotic chloramphenicol in the treatment of victims with burns of the face II-IIIа degrees ...
I. V. Chmyrev, Ya. L. Butrin
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Conservative treatment of a psoas hematoma revealed by a lower limb palsy

The Pan African Medical Journal, 2017
The psoas hematoma is a rare complication of the anticoagulation therapy. It cause abdominal or lumbar pain, muscle dysfunction and sometimes nerve palsy. The optimal treatment is not well established, surgery or conservative treatment?
Zidouh Saad, Belkouch Ahmed, Rafai Mostafa, Bakkali Hicham, Belyamani Lahcen   +4 more
doaj   +1 more source

Sacroiliac luxations in cats: Surgery or conservative treatment?

Revista Científica, 2022
Sacroiliac luxations constitute an important part of hip fractures. In the treatment phase, a choice should be made between surgical and conservative treatment.
Ziya Yurtal, Muhammed Enes Altuğ, Cafer Tayer İşler, Mehmet Zeki Yılmaz Deveci, İbrahim Alakuş, Ömer Kırgız, Halil Alakuş, Ufuk Kaya   +7 more
doaj   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

CLINICAL CASE OF CHYLOPERICARDIUM IN A PATIENT AFTER VATS LOBECTOMY

Инновационная медицина Кубани, 2019
Chylopericardium is a rare medical condition when in the pericardial cavity chylous fluid is found. It contains high concentrations of triglycerids, with development of progressive cardiac insufficiency.
A. M. Bostanova, S. D. Sitnik, V. A. Zhikharev   +2 more
doaj   +2 more sources

Precision‐Optimised Post‐Stroke Prognoses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error metrics across samples of patients whose outcomes are known.
Thomas M. H. Hope, Howard Bowman, Rachel M. Bruce, Alex P. Leff, Cathy J. Price   +4 more
wiley   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
wiley   +1 more source

Conservative treatment in acute appendicitis

Journal of Nepal Medical Association, 2010
INTRODUCTION: Acute appendicitis is one of the commonest surgical problems and appendectomy is one of the most commonly done operations in the emergency world wide.
G R Paudel, CS Agrawal, R Regmi, S Agrawal   +3 more
doaj   +1 more source