Results 1 to 10 of about 1,050,400 (267)

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects

Frontiers in Pharmacology, 2023
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This study aimed to evaluate the safety, tolerability, and pharmacokinetics of HSK16149 after single and multiple doses in healthy Chinese ...
Qian Chen, Qian Chen, Qian Chen, Qingqing Wu, Qingqing Wu, Qingqing Wu, Rong Song, Rong Song, Rong Song, Yating Wang, Yating Wang, Yating Wang, Mengqi Zhang, Mengqi Zhang, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Wei Wang, Wei Wang, Jingying Jia, Jingying Jia, Jingying Jia, Chen Yu, Chen Yu, Chen Yu, Yanmei Liu, Yanmei Liu, Yanmei Liu   +28 more
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Safety and immunogenicity of a modified COVID-19 mRNA vaccine, SW-BIC-213, as a heterologous booster in healthy adults: an open-labeled, two-centered and multi-arm randomised, phase 1 trialResearch in context

EBioMedicine, 2023
Summary: Background: We assessed the safety and immunogenicity of a core–shell structured lipopolyplex (LPP) based COVID-19 mRNA vaccine, SW-BIC-213, as a heterologous booster in healthy adults.
Yu-Zhou Gui, Xue-Ning Li, Jing-Xin Li, Ming-Yun Shen, Mei-Wei Zhang, Ye Cao, Hong-Rong Xu, Hui Li, Jie Cheng, Liang Pan, Ying-Lei Yi, Li-Yu Liang, Cheng-Yin Yu, Gang-Yi Liu, Chen Yu, Bi-Jie Hu, Feng-Cai Zhu, Fei Liang, Haifa Shen, Jing-Ying Jia, Hang-Wen Li, Jian Zhou, Jia Fan   +22 more
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Consistent posets [PDF]

Soft Computing, 2021
AbstractWe introduce so-called consistent posets which are bounded posets with an antitone involution$$'$$′where the lower cones of$$x,x'$$x,x′and of$$y,y'$$y,y′coincide provided thatx, yare different from 0, 1 and, moreover, ifx, yare different from 0, then their lower cone is different from 0, too.
Ivan Chajda, Helmut Länger
openaire   +3 more sources

The repeatability and consistency of different methods for measuring the volume parameters of the primary rectal cancer on diffusion weighted images

Frontiers in Oncology, 2023
BackgroundTo determine the reproducibility of measuring the gross total volume (GTV) of primary rectal tumor with manual and semi-automatic delineation on the diffusion-weighted image (DWI), examine the consistency of using the same delineation method on
Yong-juan Qiu, Lin-Li Zhou, Jun Li, Yi-fei Zhang, Yong Wang, Yan-song Yang   +5 more
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Time-Consistent and Market-Consistent Evaluations [PDF]

SSRN Electronic Journal, 2011
We consider evaluation methods for payoffs with an inherent financial risk as encountered for instance for portfolios held by pension funds and insurance companies. Pricing such payoffs in a way consistent to market prices typically involves combining actuarial techniques with methods from mathematical finance.
Mitja Stadje, Antoon Pelsser
openaire   +4 more sources

Homoplasy as an Auxiliary Criterion for Species Delimitation

Microorganisms, 2021
Homoplasy is a sort of noise in phylogenetic reconstructions, due to the accumulation of backmutations, convergent evolution and horizontal gene transfer (HGT), which is considered the major trigger of homoplasy in microorganism for its massive presence.
Angela Conti, Debora Casagrande Pierantoni, Vincent Robert, Gianluigi Cardinali, Laura Corte   +4 more
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Local Consistency of Smoothed Particle Hydrodynamics (SPH) in the Context of Measure Theory

Frontiers in Applied Mathematics and Statistics, 2022
The local consistency of the method of Smoothed Particle Hydrodynamics (SPH) is proved for a multidimensional continuous mechanical system in the context of measure theory.
Otto Rendón, Otto Rendón, Gilberto D. Avendaño, Jaime Klapp, Leonardo Di G. Sigalotti, Carlos A. Vargas   +5 more
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Consistency of triage scores by presenting complaint pre‐ and post‐implementation of a real‐time electronic triage decision support tool

Journal of the American College of Emergency Physicians Open, 2020
Objective eCTAS is a real‐time electronic decision‐support tool designed to standardize the application of the Canadian Triage and Acuity Scale (CTAS).
Shelley L. McLeod, Cameron Thompson, Bjug Borgundvaag, Lehana Thabane, Howard Ovens, Steve Scott, Tamer Ahmed, Keerat Grewal, Joy McCarron, Brooke Filsinger, Nicole Mittmann, Andrew Worster, Thomas Agoritsas, Michael Bullard, Gordon Guyatt   +14 more
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Comparison of biomechanical analysis results using different musculoskeletal models for children with cerebral palsy

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Musculoskeletal model-based simulations have gained popularity as a tool for analyzing human movement biomechanics. However, when examining the same gait, different models with varying anatomical data and assumptions may produce ...
Zhibo Jing, Zhibo Jing, Zhibo Jing, Jianda Han, Jianda Han, Jianda Han, Jianda Han, Juanjuan Zhang, Juanjuan Zhang, Juanjuan Zhang, Juanjuan Zhang   +10 more
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标准化培训流程对护士评定格拉斯哥昏迷评分可靠性的影响 The Effect of Standardized Training on the Reliability of Glasgow Coma Score Evaluation by Nurses

Zhongguo cuzhong zazhi, 2023
目的 评价标准化培训流程对护士进行GCS评分可靠性的影响。 方法 基于目前GCS评估方法，采用文字讲解、测验和临床实践培训一体化的标准化培训流程，进行针对护士的评分规范培训。前瞻性、连续纳入收治于首都医科大学附属北京天坛医院神经重症医学科的危重神经系统疾病患者。选取20名低年资（工作2年以内）护士，在进行标准化GCS评分培训前和培训后分别对100例神经重症患者进行GCS评分。采用组内相关系数比较接受标准化培训流程前后，护士对GCS评分评价的一致性。此外，以做培训的神经重症专科医师的GCS评分为金标准 ...
王艳新，袁媛，徐明，晁明珠，聂曦明
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