Results 61 to 70 of about 315,857 (305)
On the cost-complexity of multi-context systems [PDF]
, 2014 Multi-context systems provide a powerful framework for modelling information-aggregation systems featuring heterogeneous reasoning components. Their execution can, however, incur non-negligible cost. Here, we focus on cost-complexity of such systems.
Novák, Peter, Witteveen, Cees
core
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Consistent refinement of submitted models at CASP using a knowledge‐based potential [PDF]
Proteins: Structure, Function, and Bioinformatics, 2010 AbstractProtein structure refinement is an important but unsolved problem; it must be solved if we are to predict biological function that is very sensitive to structural details. Specifically, critical assessment of techniques for protein structure prediction (CASP) shows that the accuracy of predictions in the comparative modeling category is often ...
Nir Kalisman +2 more
openaire +3 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
The Consistency of the CADIAG-2 Knowledge Base: A Probabilistic Approach [PDF]
, 2010 The paper presents the methodology and the results of checking consistency of the knowledge base of CADIAG-2, a large-scale medical expert system. Such knowledge base consists of a large collection of rules representing knowledge about various medical entities (symptoms, signs, diseases...) and relationships between them. The major portion of the rules
Bijan Parsia +2 more
openaire +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Kiralnost - ususret 160. obljetnici Pasteurova otkrića [PDF]
Kemija u Industriji, 2007 The presented review on chirality is dedicated to the centennial birth anniversary of Nobel laureate Vladimir Prelog and 160 years of Pasteur's discovery of chirality on tartrates.
Kojić-Prodić, B., Molčanov, K.
doaj
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Harnessing Large Language Models for Digital Building Logbook Implementation
BuildingsDigital Building Logbooks (DBLs) have been proposed to preserve lifecycle data across the design, construction, operation, and renovation phases of buildings.
Alon Urlainis +2 more
doaj +1 more source
Journal of Eating Disorders, 2017 Background Outpatient treatment studies of anorexia nervosa (AN) are notoriously hard to conduct given the ambivalence of the patient group and high drop-out rates.
Tracey D. Wade +6 more
doaj +1 more source