Results 71 to 80 of about 328,022 (293)

Using consistency-driven pairwise comparisons in knowledge-based systems [PDF]

Proceedings of the sixth international conference on Information and knowledge management, 1997
Knowledge acquisition often requires the assessment of qualitative stimuli (e.g., criteria or priorities) such as public safety or the degree of environmental damage. Weights, reflecting the relative importance of the objectives concerned are one of the most commonly used solutions for this kind of data.
Waldemar W. Koczkodaj, Michael W. Herman, Marian Orłowski   +2 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A \textsf{C++} reasoner for the description logic $\shdlssx$ (Extended Version)

, 2018
We present an ongoing implementation of a \ke\space based reasoner for a decidable fragment of stratified elementary set theory expressing the description logic $\dlssx$ (shortly $\shdlssx$).
Cantone, Domenico, Nicolosi-Asmundo, Marianna, Santamaria, Daniele Francesco   +2 more
core  

Synthesizing and executing plans in Knowledge and Action Bases [PDF]

, 2016
We study plan synthesis for a variant of Knowledge and Action Bases (KABs). KABs have been recently introduced as a rich, dynamic framework where states are full-fledged description logic (DL) knowledge bases (KBs) whose extensional part is manipulated ...
Calvanese, Diego, Montali, Marco, Patrizi, Fabio, Stawowy, Michele   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Methodology for testing and validating knowledge bases [PDF]

A test and validation toolset developed for artificial intelligence programs is described. The basic premises of this method are: (1) knowledge bases have a strongly declarative character and represent mostly structural information about different ...
Krishnamurthy, C., Padalkar, S., Purves, B. R., Sztipanovits, J.   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Prompt-guided LLM agent for end-to-end ontology learning

Ìнформаційні технології та компʼютерна інженерія
Turning the vast knowledge of large language models (LLMs) into logical, machine-interpretable ontologies poses a difficult task. Conventional single-prompt strategies often generated ambiguous or mutually inconsistent triples could not be merged safely ...
Ya. Teplyi, D. Dosyn
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source