Results 61 to 70 of about 328,022 (293)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A Methodological Framework for Runtime Ontology Evolution in Dynamic Environments

open access: yesApplied Sciences
Intelligent systems operating in real-world environments are often required to make decisions in contexts that are only partially known at design time. In such scenarios, the assumption of a static and fully specified knowledge base becomes unrealistic ...
Valeria Seidita   +2 more
doaj   +1 more source

Pharyngocutaneous fistulae after total laryngectomy: a systematic review Fístula faringocutánea posterior a la laringectomía total: revisión sistemática Fístula faringocutânea após laringectomia total: revisão sistemática

open access: yesRevista Latino-Americana de Enfermagem, 2008
Nursing care to patients after total laryngectomy should be based on scientific knowledge. Evidence-based practice is a type of approach that stimulates the use of research results in clinical practice.
Mary Elizabeth de Santana   +1 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Optimizing the computation of overriding

open access: yes, 2015
We introduce optimization techniques for reasoning in DLN---a recently introduced family of nonmonotonic description logics whose characterizing features appear well-suited to model the applicative examples naturally arising in biomedical domains and ...
BC Grau   +17 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Harnessing Large Language Models for Digital Building Logbook Implementation

open access: yesBuildings
Digital Building Logbooks (DBLs) have been proposed to preserve lifecycle data across the design, construction, operation, and renovation phases of buildings.
Alon Urlainis   +2 more
doaj   +1 more source

Kiralnost - ususret 160. obljetnici Pasteurova otkrića [PDF]

open access: yesKemija u Industriji, 2007
The presented review on chirality is dedicated to the centennial birth anniversary of Nobel laureate Vladimir Prelog and 160 years of Pasteur's discovery of chirality on tartrates.
Kojić-Prodić, B., Molčanov, K.
doaj  

Comparative efficacy of pharmacological and non-pharmacological interventions for the acute treatment of adult outpatients with anorexia nervosa: study protocol for the systematic review and network meta-analysis of individual data

open access: yesJournal of Eating Disorders, 2017
Background Outpatient treatment studies of anorexia nervosa (AN) are notoriously hard to conduct given the ambivalence of the patient group and high drop-out rates.
Tracey D. Wade   +6 more
doaj   +1 more source

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