Results 71 to 80 of about 324,780 (301)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A Comprehensive Framework for Controlled Query Evaluation, Consistent Query Answering and KB Updates in Description Logics [PDF]
, 2018 In this extended abstract we discuss the relationship between confidentiality-preserving frameworks and inconsistency-tolerant repair and update semantics in Description Logics (DL).
Lembo, Domenico +2 more
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Prompt-guided LLM agent for end-to-end ontology learning
Ìнформаційні технології та компʼютерна інженеріяTurning the vast knowledge of large language models (LLMs) into logical, machine-interpretable ontologies poses a difficult task. Conventional single-prompt strategies often generated ambiguous or mutually inconsistent triples could not be merged safely ...
Ya. Teplyi, D. Dosyn
doaj +1 more source
A set-based reasoner for the description logic $\shdlssx$ (Extended Version)
, 2018 We present a \ke-based implementation of a reasoner for a decidable fragment of (stratified) set theory expressing the description logic $\dlssx$ ($\shdlssx$, for short). Our application solves the main TBox and ABox reasoning problems for $\shdlssx$. In
Cantone, Domenico +2 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Categorization and Pathology of Persian Stylistic Researches [PDF]
Literary Arts, 2014 In following article, surveys and researches about Persian style were categorized in two branches of historical and formalistic styles Mohammad Taghi Bahar founded stylistics as an autonomous knowledge by publishing his book, History of the evolution of ...
Maryam Dorpar
doaj +1 more source
A \textsf{C++} reasoner for the description logic $\shdlssx$ (Extended Version)
, 2018 We present an ongoing implementation of a \ke\space based reasoner for a decidable fragment of stratified elementary set theory expressing the description logic $\dlssx$ (shortly $\shdlssx$).
Cantone, Domenico +2 more
core
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Methodology for testing and validating knowledge bases [PDF]
A test and validation toolset developed for artificial intelligence programs is described. The basic premises of this method are: (1) knowledge bases have a strongly declarative character and represent mostly structural information about different ...
Krishnamurthy, C. +3 more
core +1 more source