Results 51 to 60 of about 165,998 (220)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Topics in computational learning theory and graph algorithms [PDF]
, 1990 "The distribution-independent model of concept learning from examples (""PAC-learning"") due to Valiant is investigated. It has previously been shown that the existence of an Occam algorithm for a class of concepts is a sufficient condition for the PAC ...
Board, Raymond Acton
core
Transcription of P. infestans genes encoding ribosomal proteins. [PDF]
, 2016 The heat map shows the per-gene normalized expression, based on microarrays, of the genes in nonsporulating hyphae (HY), sporangia (SP), sporangia chilled to induce their cleavage into zoospores (CL), motile zoospores (ZO), and germinated cysts forming ...
Kalina Andreeva (383623) +3 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Additional file 4 of A heat-sensitive Osh protein controls PI4P polarity [PDF]
, 2020 Figure S2. Stt4 PIK patches localize to ER-PM contact sites and contribute to heat stress-induced PI4P signaling. (a) The Stt4 PI4K generates PI4P at the PM.
Christopher J. Stefan (8576163) +7 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Tissue-specific density of wFlu in sugar- and blood-fed adult female Ae. fluviatilis. [PDF]
, 2013 Graphs showing the absolute (A) and relative (B) densities of wFlu in different tissues of adult females of the wildtype strain (wolb+) of the mosquito Ae. fluviatilis.
Daniela da Silva Gonçalves (394389) +3 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source